PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1. - Wikidata - awgldk - TriplyDB

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

http://www.wikidata.org/entity/Q34169736

about

Ferritin light chain interacts with PEN-2 and affects γ-secretase activity Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin Trafficking regulation of proteins in Alzheimer's disease Toward the structure of presenilin/γ-secretase and presenilin homologs APP processing in Alzheimer's disease A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex Proteolytic processing of Alzheimer's β-amyloid precursor protein Assembly, trafficking and function of gamma-secretase Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1 Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway Gamma-secretase complex assembly within the early secretory pathway Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.PGC-1α overexpression exacerbates β-amyloid and tau deposition in a transgenic mouse model of Alzheimer's disease.Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease.Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.Increased expression of PS1 is sufficient to elevate the level and activity of γ-secretase in vivo.Phosphorylation of nicastrin by SGK1 leads to its degradation through lysosomal and proteasomal pathways.Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space.Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREB Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.Activation and intrinsic gamma-secretase activity of presenilin 1.And four equals one: presenilin takes the gamma-secretase role by itself.5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.The γ-secretase complex: from structure to function.Transcriptional Regulation of TMP21 by NFAT.Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex.Pathological and physiological functions of presenilins.Pharmacologic blockade of 5-lipoxygenase improves the amyloidotic phenotype of an Alzheimer's disease transgenic mouse model involvement of γ-secretase Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy.Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.Presenilin function and gamma-secretase activity.

P2860

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P2860

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

http://www.wikidata.org/entity/Q34169736

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

@ast

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

@en

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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type

label

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

@en

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

@nl

prefLabel

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

@ast

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

@en

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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P1433

Journal of Biological Chemistry

P1476

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

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P2093

Benny S Kim

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Gang Yu

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Gopal Thinakaran

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Hahn-Jun Lee

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Hong Wang

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Hongqiao Li

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Huaxi Xu

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Sanjiv Shah

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Tae-Wan Kim

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Wen-jie Luo

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7850-7854

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scholarly article

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10.1074/JBC.C200648200

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10

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278

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5480362

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