5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
about
The 5-lipoxygenase pathway: oxidative and inflammatory contributions to the Alzheimer's disease phenotypeCysteinyl Leukotrienes and Their Receptors: Emerging Therapeutic Targets in Central Nervous System Disorders(-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA/p75NTR signaling in APP/PS1 transgenic mice.FLAP pharmacological blockade modulates metabolism of endogenous tau in vivo .Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.Zileuton restores memory impairments and reverses amyloid and tau pathology in aged Alzheimer's disease miceGamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's diseaseZileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles.2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivoDegradation of gamma secretase activating protein by the ubiquitin-proteasome pathway.Transcriptional regulation of β-secretase-1 by 12/15-lipoxygenase results in enhanced amyloidogenesis and cognitive impairmentsNew pathway links γ-secretase to inflammation and memory while sparing notch.Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidenceAdeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice.Involvement of 5-lipoxygenase activating protein in the amyloidotic phenotype of an Alzheimer's disease mouse model5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease.5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5.Knockout of 5-lipoxygenase prevents dexamethasone-induced tau pathology in 3xTg miceNeuroprotective effect of arctigenin via upregulation of P-CREB in mouse primary neurons and human SH-SY5Y neuroblastoma cells.Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.Modulation of lipopolysaccharide-induced memory insult, γ-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase.Novel lipid signaling pathways in Alzheimer's disease pathogenesis.Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.Vitamin E in aging, dementia, and Alzheimer's disease.The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegeneration.The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease.Cysteinyl Leukotrienes as Potential Pharmacological Targets for Cerebral Diseases.P450 Eicosanoids and Reactive Oxygen Species Interplay in Brain Injury and Neuroprotection.The 5-Lipoxygenase as modulator of Alzheimer's γ-secretase and therapeutic target.Pharmacologic blockade of 12/15-lipoxygenase ameliorates memory deficits, Aβ and tau neuropathology in the triple-transgenic mice.Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease.Dissecting the Role of 5-Lipoxygenase in the Homocysteine-Induced Alzheimer's Disease Pathology.The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy.Brain 5-lipoxygenase over-expression worsens memory, synaptic integrity, and tau pathology in the P301S mice.Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.Caspase-3-dependent cleavage of Akt modulates tau phosphorylation via GSK3β kinase: implications for Alzheimer's disease.Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related DiseasesTargeted metabolomics reveals altered oxylipin profiles in plasma of mild cognitive impairment patients
P2860
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P2860
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@ast
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@en
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@nl
type
label
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@ast
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@en
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@nl
prefLabel
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@ast
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@en
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@nl
P2860
P356
P1433
P1476
5-lipoxygenase as an endogenous modulator of amyloid β formation in vivo.
@en
P2093
Domenico Praticò
P2860
P356
10.1002/ANA.22234
P577
2010-11-17T00:00:00Z