Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations.
about
Ephs and ephrins in cancer: ephrin-A1 signallingGene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis.Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5Identification and characterization of Nanobodies targeting the EphA4 receptor.Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.Promiscuous and specific recognition among ephrins and Eph receptorsDevelopment and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptorUnique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulationsEph/ephrin signaling in epidermal differentiation and diseaseEphrinA1 is released in three forms from cancer cells by matrix metalloproteases.Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion.Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor.Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase.Regulation of signaling interactions and receptor endocytosis in growing blood vessels.Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist.Coordinated Eph-ephrin signaling guides migration and axon targeting in the avian auditory system.EPHA2 Polymorphisms in Estonian Patients with Age-Related Cataract.
P2860
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P2860
Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
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2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Crystal structure of the ligan ...... ls two distinct conformations.
@ast
Crystal structure of the ligan ...... ls two distinct conformations.
@en
Crystal structure of the ligan ...... ls two distinct conformations.
@nl
type
label
Crystal structure of the ligan ...... ls two distinct conformations.
@ast
Crystal structure of the ligan ...... ls two distinct conformations.
@en
Crystal structure of the ligan ...... ls two distinct conformations.
@nl
prefLabel
Crystal structure of the ligan ...... ls two distinct conformations.
@ast
Crystal structure of the ligan ...... ls two distinct conformations.
@en
Crystal structure of the ligan ...... ls two distinct conformations.
@nl
P2093
P2860
P1476
Crystal structure of the ligan ...... ls two distinct conformations.
@en
P2093
Dimitar B Nikolov
Juha P Himanen
Nikhil Singla
Sari Paavilainen
Yehuda Goldgur
P2860
P304
P356
10.1016/J.BBRC.2010.07.109
P407
P577
2010-08-01T00:00:00Z