Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
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The Role of Ephs and Ephrins in Memory FormationTargeting the Eph System with Peptides and Peptide ConjugatesEph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiationEphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in miceAn extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly.Dimeric Architecture of the Hendra Virus Attachment Glycoprotein: Evidence for a Conserved Mode of AssemblyStructurally encoded intraclass differences in EphA clusters drive distinct cell responsesInsights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5Discovery and characterization of a novel cyclic peptide that effectively inhibits ephrin binding to the EphA4 receptor and displays anti-angiogenesis activityIdentification and characterization of Nanobodies targeting the EphA4 receptor.Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.Altered distribution of the EphA4 kinase in hippocampal brain tissue of patients with Alzheimer's disease correlates with pathologyProtein dynamics and conformational selection in bidirectional signal transduction.Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations.Promiscuous and specific recognition among ephrins and Eph receptorsCrystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations.EphrinA4 mimetic peptide targeted to EphA binding site impairs the formation of long-term fear memory in lateral amygdala.HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery.Oligomerization and nanocluster organization render specificity.Development and structural analysis of a nanomolar cyclic peptide antagonist for the EphA4 receptorUnique structure and dynamics of the EphA5 ligand binding domain mediate its binding specificity as revealed by X-ray crystallography, NMR and MD simulationsDistinctive Structure of the EphA3/Ephrin-A5 Complex Reveals a Dual Mode of Eph Receptor Interaction for Ephrin-A5.A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activationDual microRNA Screens Reveal That the Immune-Responsive miR-181 Promotes Henipavirus Entry and Cell-Cell Fusion.Investigation of the interactions between the EphB2 receptor and SNEW peptide variants.Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor.Acute delivery of EphA4-Fc improves functional recovery after contusive spinal cord injury in rats.Tie2 and Eph receptor tyrosine kinase activation and signaling.EPH-EPHRIN in human gastrointestinal cancersCells under siege: viral glycoprotein interactions at the cell surface.Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.Glycoengineering of EphA4 Fc leads to a unique, long-acting and broad spectrum, Eph receptor therapeutic antagonist.Axo-Glia Interaction Preceding CNS Myelination Is Regulated by Bidirectional Eph-Ephrin Signaling.Dimerization of the EphA1 receptor tyrosine kinase transmembrane domain: Insights into the mechanism of receptor activation.Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes.Sizes of interface residues account for cross-class binding affinity patterns in Eph receptor-ephrin families.Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs.Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study.
P2860
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P2860
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@ast
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@en
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@nl
type
label
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@ast
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@en
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@nl
prefLabel
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@ast
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@en
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@nl
P2093
P2860
P50
P3181
P1433
P1476
Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling
@en
P2093
A Radu Aricescu
E Yvonne Jones
Nahid Rahman-Huq
Raymond J Owens
P2860
P304
P3181
P356
10.1016/J.STR.2009.07.018
P577
2009-10-14T00:00:00Z