Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation - Wikidata - awgldk - TriplyDB

Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation

Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation

http://www.wikidata.org/entity/Q34170762

about

The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response Targeting the TAM Receptors in Leukemia Contribution of Defective PS Recognition and Efferocytosis to Chronic Inflammation and Autoimmunity Association of plasma levels of Protein S with disease severity in multiple sclerosis.Overexpression of MERTK receptor tyrosine kinase in epithelial cancer cells drives efferocytosis in a gain-of-function capacity.Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities.Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis TAM receptor deficiency affects adult hippocampal neurogenesis.TAM receptor signaling in immune homeostasis.The AXL Receptor is a Sensor of Ligand Spatial Heterogeneity Warfarin Blocks Gas6-Mediated Axl Activation Required for Pancreatic Cancer Epithelial Plasticity and Metastasis The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles.Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Behçet's disease.MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation.Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase.Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow.Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells.A miR-7/GAS6/TYRO3 axis regulates the growth and invasiveness of sorafenib-resistant cells in human hepatocellular carcinoma.A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.TAM receptor tyrosine kinase function and the immunopathology of liver disease.Clearance of apoptotic neutrophils and resolution of inflammation.Phosphatidylserine Is the Signal for TAM Receptors and Their Ligands.Antagonistic Coevolution of MER Tyrosine Kinase Expression and Function.Small molecule inhibition of Axl receptor tyrosine kinase potently suppresses multiple malignant properties of glioma cells.Protein S drives oral squamous cell carcinoma tumorigenicity through regulation of AXL.Small molecule inhibitors block Gas6-inducible TAM activation and tumorigenicity GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance.Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6.Inhibition of type I interferon responses by adenovirus serotype-dependent Gas6 binding.The TAM receptor Tyro3 regulates myelination in the central nervous system.Function of Axl receptor tyrosine kinase in non-small cell lung cancer.A novel MERTK mutation causing retinitis pigmentosa.Age-related changes in expression and signaling of TAM receptor inflammatory regulators in monocytes.The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.Protein S Protects against Podocyte Injury in Diabetic Nephropathy.MerTK as a therapeutic target in glioblastoma.

P2860

Q27928010-4048F35F-9134-47C2-BD16-2BDFB9B8F365 Q28072503-78119552-3546-49A4-A456-B2065044E2CF Q28078654-8EDCB05F-2D8E-43C1-8F14-8478886C8A50 Q28397407-E3A1791A-425C-4F1E-A9E7-D49E99815367 Q33692556-87CDC192-4E73-4F53-AF50-2CBD07B6F245 Q34170756-0FB52879-2206-47C2-9FDC-FB7AE18A64B1 Q34390266-24CEEC95-134A-4C71-81E2-0827014AA520 Q34614563-E4347B39-BA97-4937-897E-870608E31285 Q35553941-656D03B1-F094-4503-A398-97FBF9A23BF0 Q35819380-B82F79FE-DEB9-44EA-8496-514A89F4F46A Q35904042-7205889B-00EE-4474-B770-5D7372C97CA1 Q36067893-2306764E-07D7-4F7D-B5E2-99AE691CBE5F Q36898211-07253366-8F01-4EBF-A7FF-80D6B4727AD6 Q36933960-24530E8A-5F01-43A7-88A6-E30235A91137 Q37183630-9CB90AA9-98AF-4C46-A768-0125435C50C5 Q37233198-29ABD06B-FCA2-4CF4-92AF-F0E248D5C259 Q37292436-8FD1E4FC-A5A2-41E7-88B4-F8359D0FF150 Q37397455-D1B40646-E793-4270-84A3-4F4CAABD8551 Q37714206-729A941F-BCC6-49CD-B92F-7F1D7E3E6076 Q38612171-ACD00742-4E51-40EC-AD78-B24ABD7A742A Q38704022-CCDE4133-D0E7-428A-90B0-3564AFEF73C6 Q38729745-D7DD0537-02D7-4685-B706-6B6344183A33 Q38936566-5D910644-C650-4D93-8EA9-AE6E7B1E1429 Q39451964-83F12FD8-AC17-4997-A486-F9A1F9943665 Q40062737-5A2BDC3C-856B-418A-8CC1-097C21D2B6F2 Q41061766-D35EDB11-5835-4DE3-A83F-8C8BD6EC660C Q41847773-12C9C7EE-0AF0-4CD5-8759-D4AD0DF47DB5 Q41940444-B9EDE9E1-4898-426F-8642-3B89B277E3FF Q42288454-0D6F266D-3836-4C53-804B-E0D765A5BB20 Q47164001-D698E5E4-83FC-40EB-BA70-647DAFCF973B Q47242905-060B36A0-9299-4014-9132-F77D650B2DF4 Q47812174-1287E3B0-E9D3-47FC-AAB5-2EDD32D1605B Q49636410-86D3F1F0-CB56-42B6-889A-8E12E8A613E7 Q51024891-FA88F9EE-C854-43BE-88D0-A715224D50DE Q51764991-63EB21E6-3E15-4FF5-9506-E43EE5503D8C Q52669235-487E628F-44E5-44D7-B2B9-D1543A952A90 Q52671172-E0A47012-3B55-4405-9528-D5C90EC606A1 Q52765904-D3E47F10-B90A-47CA-917E-AC7DA549E13B

P2860

Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation

http://www.wikidata.org/entity/Q34170762

description

2014 nî lūn-bûn

@nan

2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年学术文章

@wuu

2014年学术文章

@zh-cn

2014年学术文章

@zh-hans

2014年学术文章

@zh-my

2014年学术文章

@zh-sg

2014年學術文章

@yue

name

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@ast

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@en

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@nl

type

label

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@ast

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@en

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@nl

prefLabel

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@ast

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@en

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@nl

P1433

Q34170762-3E3A44E7-74BE-4BCC-8E72-DA5A3A3D9DEF

P1476

Q34170762-07BAEB3A-0935-4E8A-9F9F-68066F5A56DD

P2093

Q34170762-0BD6C010-BDA4-4DD2-B006-764850B682A8

Q34170762-20258435-D269-4790-A7BB-DA2D3D56F03F

Q34170762-5502F8A7-07C7-4E4A-BCBE-4B642BE253F2

Q34170762-9EF1EED7-2873-481D-A8AC-8C3E79B81D2E

Q34170762-B06684BC-5448-4C5D-BD1D-EFBAA8032E50

Q34170762-BD27139F-6287-4C64-84BD-07D73115DD40

Q34170762-CEFEEE44-84FB-4B16-8EB5-F3F13E252AAA

Q34170762-E1A45488-0988-401C-8CDA-DFB75C6FB331

Q34170762-EDAA4464-7BF4-40B1-B7A3-58AF0E7DE753

P2860

Q34170762-08FFB209-DF4B-4434-A809-A391C9C76C2D

Q34170762-0C38D895-7AA7-4E44-8A2F-656082A53121

Q34170762-11FB159F-753E-4D3E-B8E2-2860EC64AD7A

Q34170762-12107762-DA38-4189-ACF5-E5DF4CD7FAEC

Q34170762-12A6E8B2-6BAF-4ADA-99F7-74009C0A8CA2

Q34170762-14E1DA9D-1DA9-46C1-9236-B455215FBCD4

Q34170762-171E46A7-EDD2-4206-8D33-4E453893DBC9

Q34170762-19D2218C-5F09-4BA6-8FBD-DF3464C1C003

Q34170762-22A64878-400A-44D7-B021-FAA92893D722

Q34170762-22D8B9C5-784A-4CFA-B394-3EF6412AB955

P304

Q34170762-F1A8EB70-39EE-4169-8E7B-6E6F133E8B7C

P31

Q34170762-D734AF69-C5C3-4826-B014-566AD4593187

P356

Q34170762-074BEF0C-D724-4C7B-ADC0-8A6F8A79E24C

P407

Q34170762-20B60768-0BBC-42B1-ACA4-6163050EF895

P433

Q34170762-D6F7892C-5A07-4DD1-BDF4-17FFA6050C01

P478

Q34170762-1510FEC7-8CB5-47AC-8F3F-A938A2F5CF72

P577

Q34170762-ED8E6202-63F9-4AE1-941C-09482527460E

P698

Q34170762-0EE6B01D-E06D-4115-8793-B2AB76CD4EC6

P932

Q34170762-8585283B-889E-4283-BCCB-BF8B59E4DFFA

P356

JBC.M114.569020

P1433

Journal of Biological Chemistry

P1476

Receptor tyrosine kinases, TYR ...... n of ligand-induced activation

@en

P2093

Anita L Antes

http://www.w3.org/2001/XMLSchema#string

Daniel A Calarese

http://www.w3.org/2001/XMLSchema#string

Khanh-Quynh N Nguyen

http://www.w3.org/2001/XMLSchema#string

Raymond B Birge

http://www.w3.org/2001/XMLSchema#string

Scott J Garforth

http://www.w3.org/2001/XMLSchema#string

Sergei V Kotenko

http://www.w3.org/2001/XMLSchema#string

Sergey V Smirnov

http://www.w3.org/2001/XMLSchema#string

Steve C Almo

http://www.w3.org/2001/XMLSchema#string

Wen-I Tsou

http://www.w3.org/2001/XMLSchema#string

P2860

TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine

Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood

Structural basis for Gas6-Axl signalling.

The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry

The Tyro3 receptor kinase Axl enhances macropinocytosis of Zaire ebolavirus

axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase

The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade

Cloning and mRNA expression analysis of a novel human protooncogene, c-mer

Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway

IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex

P304

25750-25763

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M114.569020

http://www.w3.org/2001/XMLSchema#string

P407

P433

37

http://www.w3.org/2001/XMLSchema#string

P478

289

http://www.w3.org/2001/XMLSchema#string

P577

2014-07-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

25074926

http://www.w3.org/2001/XMLSchema#string

P932

4162177

http://www.w3.org/2001/XMLSchema#string