A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage.
about
Combined gene/cell therapies provide long-term and pervasive rescue of multiple pathological symptoms in a murine model of globoid cell leukodystrophy.Calcium signaling in synapse-to-nucleus communicationIncreasing levels of wild-type CREB up-regulates several activity-regulated inhibitor of death (AID) genes and promotes neuronal survival.Requirement for nuclear calcium signaling in Drosophila long-term memory.Mechanism of action for NNZ-2566 anti-inflammatory effects following PBBI involves upregulation of immunomodulator ATF3.Nuclear calcium is required for human T cell activation.Synaptic Activity Drives a Genomic Program That Promotes a Neuronal Warburg Effect.Early phase of plasticity-related gene regulation and SRF dependent transcription in the hippocampusShort-term cuprizone feeding induces selective amino acid deprivation with concomitant activation of an integrated stress response in oligodendrocytes.Inversion of Sonic hedgehog action on its canonical pathway by electrical activity.The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.Synaptic NMDA receptors mediate hypoxic excitotoxic deathThe subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.Nuclear calcium signaling controls methyl-CpG-binding protein 2 (MeCP2) phosphorylation on serine 421 following synaptic activity.Tissue-type plasminogen activator protects neurons from excitotoxin-induced cell death via activation of the ERK1/2-CREB-ATF3 signaling pathway.Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.Association Between a Polymorphism (rs2071214) in Baculoviral IAP Repeat Containing 5 Gene (BIRC5) and Ischemic Stroke in Korean Population.Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome.Linking redox regulation of NMDAR synaptic function to cognitive decline during aging.CaMKII in cerebral ischemia.ATF3 expression improves motor function in the ALS mouse model by promoting motor neuron survival and retaining muscle innervation.The nuclear events guiding successful nerve regeneration.Ischemic tolerance in the brain: endogenous adaptive machinery against ischemic stress.Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-β.Microdissection and transcriptional profiling: a window into the pathobiology of preclinical prion disease.The nuclear calcium signaling target, activating transcription factor 3 (ATF3), protects against dendrotoxicity and facilitates the recovery of synaptic transmission after an excitotoxic insult.Transcriptional and Epigenetic Regulation in Injury-Mediated Neuronal Dendritic Plasticity.Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice.Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury.Activating transcription factor 3 and the nervous system.Nuclear calcium signaling regulates nuclear export of a subset of class IIa histone deacetylases following synaptic activity.Nuclear calcium signaling induces expression of the synaptic organizers Lrrtm1 and Lrrtm2Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals.Transcription factor changes following long term cerebral ischemia/reperfusion injury.Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury.Dynamic expression of ATF3 as a novel tool to study activation and migration of endogenous spinal stem cells and their role in neural repair.Extrasynaptic glutamate release through cystine/glutamate antiporter contributes to ischemic damageNuclear Calcium Buffering Capacity Shapes Neuronal Architecture.Validation of organotypical hippocampal slice cultures as an ex vivo model of brain ischemia: different roles of NMDA receptors in cell death signalling after exposure to NMDA or oxygen and glucose deprivation.
P2860
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A signaling cascade of nuclear calcium-CREB-ATF3 activated by synaptic NMDA receptors defines a gene repression module that protects against extrasynaptic NMDA receptor-induced neuronal cell death and ischemic brain damage.
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2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
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2011 թվականի մարտին հրատարակված գիտական հոդված
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2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@ast
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@en
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@nl
type
label
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@ast
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@en
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@nl
prefLabel
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@ast
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@en
A signaling cascade of nuclear ...... ath and ischemic brain damage.
@nl
P2093
P1476
A signaling cascade of nuclear ...... eath and ischemic brain damage
@en
P2093
Bettina Buchthal
Hilmar Bading
Markus Schwaninger
Oliver Dick
Roland Veltkamp
Sheng-Jia Zhang
Stefanie Hayer
Ursula Weiss
P304
P356
10.1523/JNEUROSCI.2672-10.2011
P407
P577
2011-03-01T00:00:00Z