Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives.
about
Development and application of a positive-negative selectable marker system for use in reverse genetics in Plasmodium.Crystal structure of yeast cytosine deaminase. Insights into enzyme mechanism and evolutionBacterial Cytosine Deaminase Mutants Created by Molecular Engineering Show Improved 5-Fluorocytosine-Mediated Cell Killing In vitro and In vivoProgress and problems with the use of suicide genes for targeted cancer therapyHybrid sequencing approach applied to human fecal metagenomic clone libraries revealed clones with potential biotechnological applicationsGeneration and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from yeast.Recent trends in targeted anticancer prodrug and conjugate design.Fusion enzymes containing HSV-1 thymidine kinase mutants and guanylate kinase enhance prodrug sensitivity in vitro and in vivo.Expression of the bifunctional suicide gene CDUPRT increases radiosensitization and bystander effect of 5-FC in prostate cancer cells.Design and synthesis of a beta-lactamase activated 5-fluorouracil prodrug.Neighbor effects of neurons bearing protective transgenesA novel Doxorubicin prodrug with controllable photolysis activation for cancer chemotherapyDevelopment of inhibitor-directed enzyme prodrug therapy (IDEPT) for prostate cancer.Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas.Non-invasive molecular and functional imaging of cytosine deaminase and uracil phosphoribosyltransferase fused with red fluorescence protein.Comparative analysis of enzyme and pathway engineering strategies for 5FC-mediated suicide gene therapy applications.Gene therapy and targeted toxins for glioma.A reconstituted telomerase-immortalized human corneal epithelium in vivo: a pilot studyA protein therapeutic modality founded on molecular regulation.Neoadjuvant in situ gene-mediated cytotoxic immunotherapy improves postoperative outcomes in novel syngeneic esophageal carcinoma models.A self-contained enzyme activating prodrug cytotherapy for preclinical melanoma.Mycoplasmas and cancer: focus on nucleoside metabolismRole of glutamate 64 in the activation of the prodrug 5-fluorocytosine by yeast cytosine deaminase.Gene therapy of benign gynecological diseases.Tumor-activated prodrugs--a new approach to cancer therapy.Engineered proteins: redox properties and their applications.Therapeutic potential of stem cells expressing suicide genes that selectively target human breast cancer cells: evidence that they exert tumoricidal effects via tumor tropism (review).A cell-delivered and cell-activated SN38-dextran prodrug increases survival in a murine disseminated pancreatic cancer modelInhibition of growth and induction of apoptosis in human breast cancer by transfection of gef gene.The role of herpes simplex virus-1 thymidine kinase alanine 168 in substrate specificity.Prodrug approaches for CNS deliveryAntitumor therapy mediated by 5-fluorocytosine and a recombinant fusion protein containing TSG-6 hyaluronan binding domain and yeast cytosine deaminaseDevelopment of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.Enzymes to die for: exploiting nucleotide metabolizing enzymes for cancer gene therapy.SV40 virus-like particles as an effective delivery system and its application to a vaccine carrier.The future of prodrugs - design by quantum mechanics methods.Update on oncolytic viral therapy - targeting angiogenesisProdrugs design based on inter- and intramolecular chemical processes.Using predrugs to optimize drug candidates.Targeted prodrug approaches for hormone refractory prostate cancer.
P2860
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P2860
Gene directed enzyme/prodrug therapy of cancer: historical appraisal and future prospectives.
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@ast
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@en
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@nl
type
label
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@ast
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@en
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@nl
prefLabel
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@ast
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@en
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@nl
P2860
P1476
Gene directed enzyme/prodrug t ...... aisal and future prospectives.
@en
P2093
P2860
P356
10.1002/1097-4652(2001)9999:9999<::AID-JCP1060>3.0.CO;2-H
P577
2001-04-01T00:00:00Z