Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.
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Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cells.SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cellsChinese Herbs Interfering with Cancer Reprogramming MetabolismPyruvate Kinase M2: A Potential Target for Regulating InflammationThe sweet trap in tumors: aerobic glycolysis and potential targets for therapyPyruvate kinase M2 at a glanceBiosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plantsROS homeostasis and metabolism: a dangerous liason in cancer cellsAdipose tissue dysfunction and its effects on tumor metabolismA DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effectAnticancer agent shikonin is an incompetent inducer of cancer drug resistanceSensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cellsShikonin Suppresses Skin Carcinogenesis via Inhibiting Cell ProliferationThe anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis.PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis.Anticancer targets in the glycolytic metabolism of tumors: a comprehensive reviewIncreased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathwaysPyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.Molecular pathways: regulation and targeting of kinetochore-microtubule attachment in cancerSoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents.Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer.Alkannin inhibits growth and invasion of glioma cells C6 through IQGAP/mTOR signal pathway.Transgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots.Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1.Overexpression of the M2 isoform of pyruvate kinase is an adverse prognostic factor for signet ring cell gastric cancerMolecular and Translational Classifications of DAMPs in Immunogenic Cell Death.Emerging roles of PKM2 in cell metabolism and cancer progressionAnticancer agents that counteract tumor glycolysis.PKM2 and cancer: The function of PKM2 beyond glycolysis.Evidence That Does Not Support Pyruvate Kinase M2 (PKM2)-catalyzed Reaction as a Rate-limiting Step in Cancer Cell GlycolysisNatural compounds as regulators of the cancer cell metabolismQuantitative Non-canonical Amino Acid Tagging (QuaNCAT) Proteomics Identifies Distinct Patterns of Protein Synthesis Rapidly Induced by Hypertrophic Agents in Cardiomyocytes, Revealing New Aspects of Metabolic Remodeling.Homocysteine Activates B Cells via Regulating PKM2-Dependent Metabolic Reprogramming.Immunogenicity of mammary tumor cells can be induced by shikonin via direct binding-interference with hnRNPA1.Regulation and function of pyruvate kinase M2 in cancer.Shikonin-loaded antibody-armed nanoparticles for targeted therapy of ovarian cancer.Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin.Shikonin and its derivatives: a patent review.Deregulation of glycolysis in cancer: glyceraldehyde-3-phosphate dehydrogenase as a therapeutic target.Multimodal immunogenic cancer cell death as a consequence of anticancer cytotoxic treatments.
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P2860
Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
name
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@ast
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@en
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@nl
type
label
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@ast
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@en
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@nl
prefLabel
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@ast
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@en
Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@nl
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Shikonin and its analogs inhib ...... ting tumor pyruvate kinase-M2.
@en
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P2860
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10.1038/ONC.2011.137
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2011-04-25T00:00:00Z
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P6179
1019174410