Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
about
The crystal structure of Toxoplasma gondii pyruvate kinase 1The metabolic advantage of tumor cellsIdentification of small molecule inhibitors of pyruvate kinase M2Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinaseHuman pyruvate kinase M2: a multifunctional proteinDifferential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozymePyruvate kinase: Function, regulation and role in cancerSerine and glycine metabolism in cancerPyruvate kinase M2 at a glanceAllosteric Mechanism of Pyruvate Kinase from Leishmania mexicana Uses a Rock and Lock ModelThe Trypanocidal Drug Suramin and Other Trypan Blue Mimetics Are Inhibitors of Pyruvate Kinases and Bind to the Adenosine SiteSmall Molecule Activation of PKM2 in Cancer Cells Induces Serine AuxotrophySerine is a natural ligand and allosteric activator of pyruvate kinase M2M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation.`In crystallo' substrate binding triggers major domain movements and reveals magnesium as a co-activator of Trypanosoma brucei pyruvate kinasePyruvate kinases have an intrinsic and conserved decarboxylase activityRedox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin.Insulin promotes glucose consumption via regulation of miR-99a/mTOR/PKM2 pathwayCombining structure-based pharmacophore modeling, virtual screening, and in silico ADMET analysis to discover novel tetrahydro-quinoline based pyruvate kinase isozyme M2 activators with antitumor activityMUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cellsDistinguishing the Interactions in the Fructose 1,6-Bisphosphate Binding Site of Human Liver Pyruvate Kinase That Contribute to AllosteryPyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cellsIdentification of arsenic-binding proteins in human breast cancer cellsAnalysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors.Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinaseDynamics and control of the central carbon metabolism in hepatoma cellsThe alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinaseExon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status.Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment.2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinaseExpanding the mouse embryonic stem cell proteome: combining three proteomic approaches.Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regressionPyruvate kinase M2 in blood circulation facilitates tumor growth by promoting angiogenesis.Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responsesMitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization.
P2860
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P2860
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
description
2005 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2005
@ast
im Juli 2005 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/07/12)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/07/12)
@nl
наукова стаття, опублікована в липні 2005
@uk
مقالة علمية (نشرت في 12-7-2005)
@ar
name
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@ast
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@en
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@nl
type
label
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@ast
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@en
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@nl
prefLabel
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@ast
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@en
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@nl
P2093
P3181
P356
P1433
P1476
Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
@en
P2093
Andrew D. Mesecar
Bernard D. Santarsiero
Jill D. Dombrauckas
P304
P3181
P356
10.1021/BI0474923
P407
P577
2005-07-12T00:00:00Z