Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
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PLK1, A Potential Target for Cancer TherapyPLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase.Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.Bora downregulation results in radioresistance by promoting repair of double strand breaks.Increased Notch Signaling Enhances Radioresistance of Malignant Stromal Cells Induced by Glioma Stem/ Progenitor CellsPolo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine GliomaEmerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair.Molecular profiling of childhood cancer: Biomarkers and novel therapiesMetabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targetsMicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma.Human ABCB1 (P-glycoprotein) and ABCG2 mediate resistance to BI 2536, a potent and selective inhibitor of Polo-like kinase 1An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma.Current concepts in clinical radiation oncology.The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models.Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma.Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy.The clinical and prognostic value of polo-like kinase 1 in lung squamous cell carcinoma patients: immunohistochemical analysis.The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.PLK1-associated microRNAs are correlated with pediatric medulloblastoma prognosis.Radiosensitization in esophageal squamous cell carcinoma: Effect of polo-like kinase 1 inhibition.miR-106b is overexpressed in medulloblastomas and interacts directly with PTEN.In vitro targeting of Polo-like kinase 1 in bladder carcinoma: comparative effects of four potent inhibitors.Inhibiting Polo-like kinase 1 causes growth reduction and apoptosis in pediatric acute lymphoblastic leukemia cellsDisulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide.Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines.MPS1 kinase as a potential therapeutic target in medulloblastoma.Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastomaTargeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases.Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor.The polo-like kinase 1 inhibitor volasertib synergistically increases radiation efficacy in glioma stem cells.BI2536 induces mitotic catastrophe and radiosensitization in human oral cancer cells.PLK1 inhibitor facilitates the suppressing effect of temozolomide on human brain glioma stem cells
P2860
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P2860
Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Polo-like kinase 1 (PLK1) inhi ...... ivity in medulloblastoma cells
@ast
Polo-like kinase 1 (PLK1) inhi ...... ivity in medulloblastoma cells
@en
type
label
Polo-like kinase 1 (PLK1) inhi ...... ivity in medulloblastoma cells
@ast
Polo-like kinase 1 (PLK1) inhi ...... ivity in medulloblastoma cells
@en
prefLabel
Polo-like kinase 1 (PLK1) inhi ...... ivity in medulloblastoma cells
@ast
Polo-like kinase 1 (PLK1) inhi ...... ivity in medulloblastoma cells
@en
P2093
P2860
P356
P1433
P1476
Polo-like kinase 1 (PLK1) inhi ...... ivity in medulloblastoma cells
@en
P2093
Adrian Dubuc
Andrew M Donson
Diane K Birks
Irina Alimova
Michael D Taylor
Michael H Handler
Peter S Harris
Rajeev Vibhakar
Sujatha Venkataraman
P2860
P2888
P356
10.1186/1471-2407-12-80
P407
P577
2012-03-05T00:00:00Z
P5875
P6179
1012614873