In silico evidence for DNA polymerase-beta's substrate-induced conformational change
about
Molecular dynamics study of the opening mechanism for DNA polymerase IUnfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s PathwayRegulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selectionDistinct energetics and closing pathways for DNA polymerase beta with 8-oxoG template and different incoming nucleotides.Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase.Monte Carlo, harmonic approximation, and coarse-graining approaches for enhanced sampling of biomolecular structure.Molecular dynamics-based approaches for enhanced sampling of long-time, large-scale conformational changes in biomolecules.Modeling DNA polymerase μ motions: subtle transitions before chemistry.In silico studies of the African swine fever virus DNA polymerase X support an induced-fit mechanismEffect of oxidatively damaged DNA on the active site preorganization during nucleotide incorporation in a high fidelity polymerase from Bacillus stearothermophilus.The effect of a G:T mispair on the dynamics of DNA"Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides.Energy analysis of chemistry for correct insertion by DNA polymerase beta.Sequential side-chain residue motions transform the binary into the ternary state of DNA polymerase lambda.Prechemistry versus preorganization in DNA replication fidelity.DNA pol λ's extraordinary ability to stabilize misaligned DNA.Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase betaMolecular dynamics simulations of hemoglobin A in different states and bound to DPG: effector-linked perturbation of tertiary conformations and HbA concerted dynamicsInsertion of oxidized nucleotide triggers rapid DNA polymerase openingComputational simulation strategies for analysis of multisubunit RNA polymerases.Relationship between conformational changes in pol lambda's active site upon binding incorrect nucleotides and mismatch incorporation rates.How DNA polymerase X preferentially accommodates incoming dATP opposite 8-oxoguanine on the template.Biomolecularmodeling and simulation: a field coming of age.Why nature really chose phosphate.Quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization.Mismatched base-pair simulations for ASFV Pol X/DNA complexes help interpret frequent G*G misincorporation.C(α) torsion angles as a flexible criterion to extract secrets from a molecular dynamics simulation.Subtle but variable conformational rearrangements in the replication cycle of Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) may accommodate lesion bypass.Fidelity discrimination in DNA polymerase beta: differing closing profiles for a mismatched (G:A) versus matched (G:C) base pair.
P2860
Q27320227-0FA35BD0-965C-431F-9440-686A1F46FDC7Q27679382-03E10B40-8101-4AB7-9F30-B7D595DE166FQ31086167-F5E02664-2F18-4360-B79F-C79343C1CA3CQ33274908-BB927F8D-21B5-45FE-AC21-497F191F0A48Q34069089-C6C68511-2EFF-4C4D-8BB6-447123F4688BQ34076345-650F3922-60AE-4F6D-9605-B34337EBC785Q34167258-EC74F52D-2185-4CDB-A750-4047D4D40A52Q34306952-AF2C916C-B738-4990-842C-9055E60B7576Q34352876-C5950F94-7E8C-4910-94A2-74EB6A99A065Q34501365-6EC310BE-3C18-4C8D-8FB4-F8087E544A48Q34555663-44AD2A55-AA9A-4942-A1E7-7275C9AE57F5Q34743729-6A5B7DC6-FEBB-4100-9F41-D7D0008393A1Q35037206-EFB634F9-168E-4B34-B76B-747E877B90CBQ35095792-EC49D58F-4226-472A-9BAD-1BCBA26CA68DQ35212044-0A137B0E-FBD9-4879-B58A-9074348A0691Q35278258-7647BE6B-E60B-4BD3-A0B6-A17A33F83976Q35751470-CA154EE0-34F4-4611-9863-3F610D78C40BQ36494755-DCCCE1D4-CC01-40CF-9D90-DFC9AD9168D0Q36914612-45CBBBED-F28E-427B-88C0-B4C4AB1B35CFQ37313036-C00E604B-C5D8-45C5-A029-434EAB63E4DAQ37362528-9D80BCF5-E1A8-4487-8817-6C855C6F2AD6Q37368220-C19EA7F2-820F-4E55-B0F8-F0637700C6B0Q37827906-1BEB9E2F-F850-490C-B8E2-EE8DB07E2AC9Q38073986-7B54F01F-75E1-4D66-9F38-BB81AD4AD27CQ38731525-F07570CB-4C9F-48AE-B3A3-269D02E5DDBEQ40406352-E1EF6D6D-5AFB-4DF5-8FBC-9258537B39D9Q42654422-9BFF8936-5CD4-4135-810D-BB433A86D0FDQ42943436-617A7A8D-1CA9-4F17-9836-C6C5C68F45ADQ43199649-2384EFB7-47E3-41F0-B885-1C5E793D21A7
P2860
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
description
2004 nî lūn-bûn
@nan
2004 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@ast
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@en
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@nl
type
label
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@ast
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@en
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@nl
prefLabel
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@ast
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@en
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@nl
P2860
P1433
P1476
In silico evidence for DNA polymerase-beta's substrate-induced conformational change
@en
P2093
Karunesh Arora
Tamar Schlick
P2860
P304
P356
10.1529/BIOPHYSJ.104.040915
P407
P577
2004-11-01T00:00:00Z