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The cell nucleus and aging: tantalizing clues and hopeful promisesThe mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skinMolecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a modelExome sequencing identifies a novel mutation in PIK3R1 as the cause of SHORT syndromeDermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stressLoss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerinInhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndromeAge-related changes of nuclear architecture in Caenorhabditis elegansReversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndromeHutchinson-Gilford progeria mutant lamin A primarily targets human vascular cells as detected by an anti-Lamin A G608G antibody.Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndromeLamin B1 is required for mouse development and nuclear integrityTrue lies: the double life of the nucleotide excision repair factors in transcription and DNA repairPhenotype and course of Hutchinson-Gilford progeria syndromeEpigenetic alterations in agingExome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndromeA novel homozygous p.Arg527Leu LMNA mutation in two unrelated Egyptian families causes overlapping mandibuloacral dysplasia and progeria syndromeBlocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndromeThe epidemiology of premature aging and associated comorbiditiesProgerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblastsModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesLamin A-dependent misregulation of adult stem cells associated with accelerated ageingA farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse modelA carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylationThe AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER proteinLamin A-dependent nuclear defects in human agingAltered protein dynamics of disease-associated lamin A mutantsLamin A/C truncation in dilated cardiomyopathy with conduction diseaseExpression and localization of nuclear proteins in autosomal-dominant Emery-Dreifuss muscular dystrophy with LMNA R377H mutationAging syndrome genes and premature coronary artery diseaseHallmarks of progeroid syndromes: lessons from mice and reprogrammed cellsMolecular insights into the premature aging disease progeriaThe short-lived African turquoise killifish: an emerging experimental model for ageingSearch and insights into novel genetic alterations leading to classical and atypical Werner syndromeWhen lamins go bad: nuclear structure and diseaseThe role of RecQ helicases in non-homologous end-joiningmiR-9: the sentinel of neurons in progeriaRecent advances in understanding the role of lamins in health and diseasePhysiological and Pathological Aging Affects Chromatin Dynamics, Structure and Function at the Nuclear EdgeThe hallmarks of aging
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Lamin a truncation in Hutchinson-Gilford progeria.
@ast
Lamin a truncation in Hutchinson-Gilford progeria.
@en
Lamin a truncation in Hutchinson-Gilford progeria.
@nl
type
label
Lamin a truncation in Hutchinson-Gilford progeria.
@ast
Lamin a truncation in Hutchinson-Gilford progeria.
@en
Lamin a truncation in Hutchinson-Gilford progeria.
@nl
prefLabel
Lamin a truncation in Hutchinson-Gilford progeria.
@ast
Lamin a truncation in Hutchinson-Gilford progeria.
@en
Lamin a truncation in Hutchinson-Gilford progeria.
@nl
P2093
P50
P356
P1433
P1476
Lamin a truncation in Hutchinson-Gilford progeria.
@en
P2093
Colin L Stewart
Irène Boccaccio
Pierre Cau
Rafaëlle Bernard
P356
10.1126/SCIENCE.1084125
P407
P50
P577
2003-04-17T00:00:00Z