The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin
about
Progeria: a rare genetic premature ageing disorderProgerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblastsA farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse modelMolecular insights into the premature aging disease progeriaNew look at the role of progerin in skin agingMouse models of laminopathiesRapalogs and mTOR inhibitors as anti-aging therapeuticsTemsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular PhenotypeEmbryonic senescence and laminopathies in a progeroid zebrafish modelHow Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativeInterruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotypeTRF2 and lamin A/C interact to facilitate the functional organization of chromosome endsExpression of progerin in aging mouse brains reveals structural nuclear abnormalities without detectible significant alterations in gene expression, hippocampal stem cells or behavior.Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.Diseases of the nuclear envelope.Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1.Transient monoparesis after blade plate removal in a Hutchinson-Gilford progeria syndrome patient: a case reportDNA damage and laminsMechanobiology and the microcirculation: cellular, nuclear and fluid mechanics.Metformin decreases progerin expression and alleviates pathological defects of Hutchinson-Gilford progeria syndrome cells.Differential temporal and spatial progerin expression during closure of the ductus arteriosus in neonatesClinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome.Basic principles and technologies for deciphering the genetic map of cancer.Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence.Functional coupling between the extracellular matrix and nuclear lamina by Wnt signaling in progeria.Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells.Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging.Inner nuclear membrane proteins: impact on human disease.Progeria: translational insights from cell biology.Transformation resistance in a premature aging disorder identifies a tumor-protective function of BRD4.Cellular reprogramming for understanding and treating human disease.Reversal of age-dependent nuclear morphology by inhibition of prenylation does not affect lifespan in Caenorhabditis elegansProgerin, the protein responsible for the Hutchinson-Gilford progeria syndrome, increases the unrepaired DNA damages following exposure to ionizing radiation.Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatinNuclear lamins and chromatin: when structure meets function.Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndromeSulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts.Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient miceAntisense oligonucleotide induction of progerin in human myogenic cells'Relax and Repair' to restrain aging.
P2860
Q24564144-9B42B9D8-8405-47F1-9DDD-47D39B5D8BC2Q24634195-BC27120A-BF8A-4877-9A9B-1F614C714050Q24657266-08B20490-147A-4A5D-BBCA-BFAA23D67029Q26768972-CB940404-651F-4460-AE36-D976919993DFQ26795573-3EB83C86-479D-40AE-AB7B-AD4C853E0CD2Q26829927-8D5B60BB-6B46-4AE6-B0EB-90569DB2941FQ28286510-66B96D32-C591-4646-A617-9F084CF20782Q28468499-E3D082C3-82D7-48E8-8257-610DC1F3139EQ28477557-E68A393D-02B3-4431-980C-4F8E5700AF79Q28601451-496A4582-FA64-4371-9334-191020A77B60Q28822028-DF289C5B-FDBC-451C-8DF5-A664D68C2887Q29147479-D8D85238-2F9F-48FA-84E0-07C93A56ABFDQ30619979-7C4ED8D8-062D-4FC1-A987-0119775C60A1Q33608779-83B8CAB3-8ED9-42AC-A850-58F7D93F0AFAQ33687043-0C0F149C-81D4-492C-ABBC-01B40827319DQ33730599-49F1C0BD-966C-4787-8B32-F6798E32FA94Q33738820-A3DE8D0E-77BA-4883-A3FC-FE5E708DC18EQ33844504-8B2E8C03-5020-45E8-BBDA-0CD90DE8D8DDQ33895715-39D693F8-5509-4722-A789-CFE312CC032EQ33914338-065912DB-CF9C-4D9E-84C0-1FA40CF7BEF3Q34018880-851BF2F4-7FC1-4DEF-ABDC-018B623DB029Q34033699-18A93A89-CCBC-4C4F-8A9B-CFF479DB7FE1Q34074628-C25505F6-792F-48B7-B4CB-D873C3ABFE9BQ34124543-CF3135DB-29CE-42AA-9760-E02C8A121EE8Q34137401-8F3573D4-7931-4D07-87CB-378ABBD13CCCQ34196369-D51F680C-F496-4CAA-BF8E-A90212D35358Q34248086-0A838C36-F1CB-4622-B03C-5FC65E4DA281Q34252203-807C24D4-FE9C-4F45-810C-C8A49D0296E6Q34303172-1066BF20-CA96-42E9-ADEE-FEC65B27B27CQ34324403-3ECDE3B2-A2D3-4273-8910-CF551537CCABQ34496408-EA5BB44F-75FC-496C-B541-EBE8F9493686Q34521584-B49CC6AC-863A-4AC3-8E38-A68C2F3511F4Q34532121-2FEAFA64-EADB-4C57-B510-6D0FC53F57C0Q34766646-6AC27A9A-F707-41DE-B145-1178C8A575ACQ34925545-C0C93CCC-1EAD-412F-8D24-56AA1C67F09AQ34930935-057D2F68-A452-45F6-A5A1-7A1F1C3B0C54Q35080536-E2E59D18-9100-4A0F-B054-357BAE661186Q35134204-01BFEFA9-760A-4E3D-915E-656B3D56B275Q35180565-C2CE2B12-F768-4634-8BC9-808A85A3EAA5Q35590452-519F0B10-1379-480A-A8F6-3DDB35FB1FF0
P2860
The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin
description
2007 nî lūn-bûn
@nan
2007 թուականին հրատարակուած գիտական յօդուած
@hyw
2007 թվականին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The mutant form of lamin A tha ...... f cellular aging in human skin
@ast
The mutant form of lamin A tha ...... f cellular aging in human skin
@en
The mutant form of lamin A tha ...... f cellular aging in human skin
@en-gb
The mutant form of lamin A tha ...... f cellular aging in human skin
@nl
type
label
The mutant form of lamin A tha ...... f cellular aging in human skin
@ast
The mutant form of lamin A tha ...... f cellular aging in human skin
@en
The mutant form of lamin A tha ...... f cellular aging in human skin
@en-gb
The mutant form of lamin A tha ...... f cellular aging in human skin
@nl
altLabel
The Mutant Form of Lamin A tha ...... f Cellular Aging in Human Skin
@en
prefLabel
The mutant form of lamin A tha ...... f cellular aging in human skin
@ast
The mutant form of lamin A tha ...... f cellular aging in human skin
@en
The mutant form of lamin A tha ...... f cellular aging in human skin
@en-gb
The mutant form of lamin A tha ...... f cellular aging in human skin
@nl
P2093
P2860
P3181
P1433
P1476
The mutant form of lamin A tha ...... f cellular aging in human skin
@en
P2093
David M Owens
Dayle McClintock
Desiree Ratner
Karima Djabali
Leslie B Gordon
Meepa Lokuge
P2860
P3181
P356
10.1371/JOURNAL.PONE.0001269
P407
P577
2007-01-01T00:00:00Z