Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria - Wikidata - awgldk - TriplyDB

Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria

Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria

http://www.wikidata.org/entity/Q34199931

about

Alterations in Mitochondrial Quality Control in Alzheimer's Disease Mitochondrial dysfunction: different routes to Alzheimer's disease therapy Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease Mitochondrial protein quality control: the mechanisms guarding mitochondrial health Mechanism of oxidative inactivation of human presequence protease by hydrogen peroxide Alzheimer's disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes.Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model Defective PITRM1 mitochondrial peptidase is associated with Aβ amyloidotic neurodegeneration In vitro oxidative inactivation of human presequence protease (hPreP).Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer's disease Mouse Brain Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process.Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.Epoxyeicosatrienoic acids pretreatment improves amyloid β-induced mitochondrial dysfunction in cultured rat hippocampal astrocytes Mitochondrial quality control: a matter of life and death for neurons.Genome-wide association study of language performance in Alzheimer's disease.Amyloid-β in mitochondrial disease: mutation in a human metallopeptidase links amyloidotic neurodegeneration with mitochondrial processing Mitochondrial Quality Control Proteases in Neuronal Welfare.Microglia-Synapse Pathways: Promising Therapeutic Strategy for Alzheimer's Disease.The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing.Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases.Mitochondrial Perturbation in Alzheimer's Disease and Diabetes.Mitochondrial Dysfunction Triggers Synaptic Deficits via Activation of p38 MAP Kinase Signaling in Differentiated Alzheimer's Disease Trans-Mitochondrial Cybrid Cells.Functional requirement for human pitrilysin metallopeptidase 1 arginine 183, mutated in amyloidogenic neuropathy.PITRM1 proteolyzes mitochondrial targeting peptides (presequences)

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P2860

Decreased proteolytic activity of the mitochondrial amyloid-β degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria

http://www.wikidata.org/entity/Q34199931

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年学术文章

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2011年學術文章

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name

Decreased proteolytic activity ...... r's disease brain mitochondria

@ast

Decreased proteolytic activity ...... r's disease brain mitochondria

@en

Decreased proteolytic activity ...... r's disease brain mitochondria

@nl

type

label

Decreased proteolytic activity ...... r's disease brain mitochondria

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Decreased proteolytic activity ...... r's disease brain mitochondria

@en

Decreased proteolytic activity ...... r's disease brain mitochondria

@nl

prefLabel

Decreased proteolytic activity ...... r's disease brain mitochondria

@ast

Decreased proteolytic activity ...... r's disease brain mitochondria

@en

Decreased proteolytic activity ...... r's disease brain mitochondria

@nl

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JAD-2011-101716

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Journal of Alzheimer's Disease

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Decreased proteolytic activity ...... r's disease brain mitochondria

@en

P2093

Catarina Moreira Pinho

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Elzbieta Glaser

http://www.w3.org/2001/XMLSchema#string

Heng Du

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John Xi Chen

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Lan Guo

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Nyosha Alikhani

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Shiqiang Yan

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Shirley ShiDu Yan

http://www.w3.org/2001/XMLSchema#string

P2860

Degradation of the amyloid beta-protein by the novel mitochondrial peptidasome, PreP

RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction

Amyloid plaque core protein in Alzheimer disease and Down syndrome

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model

Oxidized neprilysin in aging and Alzheimer's disease brains

Endophilin I expression is increased in the brains of Alzheimer disease patients

Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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75-87

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10.3233/JAD-2011-101716

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1

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27

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21750375

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Alzheimer's disease

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3381900

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