Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target. - Wikidata - awgldk - TriplyDB

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

http://www.wikidata.org/entity/Q34210015

about

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease Alzheimer mechanisms and therapeutic strategies Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease Amyloids: friend or foe?Role of ROS and RNS Sources in Physiological and Pathological Conditions APOE genotype and stress response - a mini review Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders Proteolytic cleavage of apolipoprotein E4 as the keystone for the heightened risk associated with Alzheimer's disease Oxidized cholesterol as the driving force behind the development of Alzheimer's disease Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression Neuroprotective Sirtuin ratio reversed by ApoE4 In silico analysis of the apolipoprotein E and the amyloid beta peptide interaction: misfolding induced by frustration of the salt bridge network Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential Reliability and validity of an algorithm for the diagnosis of normal cognition, mild cognitive impairment, and dementia: implications for multicenter research studies Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis.Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability.Apolipoprotein E - A Multifunctional Protein with Implications in Various Pathologies as a Result of Its Structural Features The effect of apolipoprotein E (ApoE) genotype on biomarkers of amyloidogenesis, tau pathology and neurodegeneration in Alzheimer's disease.The potential applications of Apolipoprotein E in personalized medicine Hypertension is a potential risk factor for vascular dementia: systematic review.BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains Soluble amyloid-β levels and late-life depression Genetic connections between neurological disorders and cholesterol metabolism Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.Apolipoprotein E: from lipid transport to neurobiology The role of apolipoprotein E in Alzheimer's disease.Reducing case ascertainment costs in U.S. population studies of Alzheimer's disease, dementia, and cognitive impairment-Part 1 Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family.Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature Brain Amyloid Deposition and Longitudinal Cognitive Decline in Nondemented Older Subjects: Results from a Multi-Ethnic Population.ApoE4-specific Misfolded Intermediate Identified by Molecular Dynamics Simulations.Promising Genetic Biomarkers of Preclinical Alzheimer's Disease: The Influence of APOE and TOMM40 on Brain Integrity.Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study

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Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

http://www.wikidata.org/entity/Q34210015

description

2005 nî lūn-bûn

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2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2005年の論文

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2005年論文

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2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

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2005年論文

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2005年论文

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name

Apolipoprotein (apo) E4 enhanc ...... potential therapeutic target.

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Apolipoprotein (apo) E4 enhanc ...... potential therapeutic target.

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type

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Apolipoprotein (apo) E4 enhanc ...... potential therapeutic target.

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Apolipoprotein (apo) E4 enhanc ...... potential therapeutic target.

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prefLabel

Apolipoprotein (apo) E4 enhanc ...... potential therapeutic target.

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Apolipoprotein (apo) E4 enhanc ...... potential therapeutic target.

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PNAS.0508693102

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Proceedings of the National Academy of Sciences of the United States of America

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Apolipoprotein (apo) E4 enhanc ...... potential therapeutic target.

@en

P2093

Elaine C Meng

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Gretchen Giedt

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Irwin D Kuntz

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Karin Müllendorff

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Karl H Weisgraber

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Liming Dong

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Robert W Mahley

http://www.w3.org/2001/XMLSchema#string

Shiming Ye

http://www.w3.org/2001/XMLSchema#string

Yadong Huang

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P2860

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

Apolipoprotein E: far more than a lipid transport protein

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

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18700-18705

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scholarly article

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10.1073/PNAS.0508693102

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51

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102

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7426540

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16344478

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