Connexins are critical for normal myelination in the CNS.
about
Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis opticaGJC2 missense mutations cause human lymphedemaMutations in the gene encoding gap junction protein alpha 12 (connexin 46.6) cause Pelizaeus-Merzbacher-like diseaseGap junctions couple astrocytes and oligodendrocytesHereditary spastic paraplegia is a novel phenotype for GJA12/GJC2 mutationsHuman oligodendrocytes express Cx31.3: function and interactions with Cx32 mutantsConnexin-47 and connexin-32 in gap junctions of oligodendrocyte somata, myelin sheaths, paranodal loops and Schmidt-Lanterman incisures: implications for ionic homeostasis and potassium siphoning.Loss-of-function GJA12/Connexin47 mutations cause Pelizaeus-Merzbacher-like diseaseThe multifaceted role of astrocytes in regulating myelinationMyelin damage and repair in pathologic CNS: challenges and prospectsGap junctions in inherited human disorders of the central nervous system.Gap junctionsCxs and Panx- hemichannels in peripheral and central chemosensing in mammalsGap junctions and hemichannels composed of connexins: potential therapeutic targets for neurodegenerative diseasesSystemic inflammation disrupts oligodendrocyte gap junctions and induces ER stress in a model of CNS manifestations of X-linked Charcot-Marie-Tooth disease.Recurrent Episodes of Stroke-Like Symptoms in a Patient with Charcot-Marie-Tooth Neuropathy X Type 1.Gestational nicotine exposure modifies myelin gene expression in the brains of adolescent rats with sex differencesCx32 and Cx47 mediate oligodendrocyte:astrocyte and oligodendrocyte:oligodendrocyte gap junction coupling.Connexin26 expression in brain parenchymal cells demonstrated by targeted connexin ablation in transgenic mice.Molecular disruptions of the panglial syncytium block potassium siphoning and axonal saltatory conduction: pertinence to neuromyelitis optica and other demyelinating diseases of the central nervous system.Connexin32 mutations cause loss of function in Schwann cells and oligodendrocytes leading to PNS and CNS myelination defectsAblation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at oligodendrocyte-astrocyte gap junctionsConnexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain.Optic neuritis in neuromyelitis optica.N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology.The extracellular matrix controls gap junction protein expression and function in postnatal hippocampal neural progenitor cellsExtensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model.Regulation of gap junction channels by infectious agents and inflammation in the CNS.Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans.Interferons, signal transduction pathways, and the central nervous system.Connexin mutant embryonic stem cells and human diseasesThe role of gap junction channels during physiologic and pathologic conditions of the human central nervous systemGap junction proteins and their role in spinal cord injuryDeletion of oligodendrocyte Cx32 and astrocyte Cx43 causes white matter vacuolation, astrocyte loss and early mortality.Disrupted SOX10 function causes spongiform neurodegeneration in gray tremor mice.Six innexins contribute to electrical coupling of C. elegans body-wall muscleConnexin37 and Connexin43 deficiencies in mice disrupt lymphatic valve development and result in lymphatic disorders including lymphedema and chylothoraxConnexin: a potential novel target for protecting the central nervous system?Gap junction communication in myelinating gliaConnexin 57 is expressed by the axon terminal network of B-type horizontal cells in the rabbit retina
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P2860
Connexins are critical for normal myelination in the CNS.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Connexins are critical for normal myelination in the CNS.
@ast
Connexins are critical for normal myelination in the CNS.
@en
Connexins are critical for normal myelination in the CNS.
@nl
type
label
Connexins are critical for normal myelination in the CNS.
@ast
Connexins are critical for normal myelination in the CNS.
@en
Connexins are critical for normal myelination in the CNS.
@nl
prefLabel
Connexins are critical for normal myelination in the CNS.
@ast
Connexins are critical for normal myelination in the CNS.
@en
Connexins are critical for normal myelination in the CNS.
@nl
P2093
P1476
Connexins are critical for normal myelination in the CNS
@en
P2093
Daniel A Goodenough
Daniela M Menichella
David L Paul
Erich Sirkowski
Steven S Scherer
P304
P356
10.1523/JNEUROSCI.23-13-05963.2003
P407
P577
2003-07-01T00:00:00Z