Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation - Wikidata - awgldk - TriplyDB

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

http://www.wikidata.org/entity/Q34213023

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The spectrum of SWI/SNF mutations, ubiquitous in human cancers Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma A decade of exploring the cancer epigenome - biological and translational implications Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer The Functional Role of PRC2 in Early T-cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) - Mechanisms and Opportunities Targeting EZH2 in cancer Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy SWI/SNF chromatin remodeling complexes and cancer Cancer epigenetics drug discovery and development: the challenge of hitting the mark SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions Coordinating cell proliferation and differentiation: Antagonism between cell cycle regulators and cell type-specific gene expression Pancreatic Cancer, A Mis-interpreter of the Epigenetic Language The role of EZH2 in tumour progression Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 The SWI/SNF genetic blockade: effects in cell differentiation, cancer and developmental diseases The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1 Disruption of hSWI/SNF complexes in T cells by WAS mutations distinguishes X-linked thrombocytopenia from Wiskott-Aldrich syndrome From neural development to cognition: unexpected roles for chromatin.Mutations of Chromatin Structure Regulating Genes in Human Malignancies.Oncogenic roles of SMARCB1/INI1 and its deficient tumors Notable roles of EZH2 and DNMT1 in epigenetic dormancy of the SHP1 gene during the progression of chronic myeloid leukaemia.Embryonic signature distinguishes pediatric and adult rhabdoid tumors from other SMARCB1-deficient cancers.Diverse roles and interactions of the SWI/SNF chromatin remodeling complex revealed using global approaches.Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors Polycomb and trithorax opposition in development and disease.Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.The molecular balancing act of p16(INK4a) in cancer and aging.Transcriptional regulation by trithorax-group proteins Inner workings and regulatory inputs that control Polycomb repressive complex 2 Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs.Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.The silencing of the SWI/SNF subunit and anticancer gene BRM in Rhabdoid tumors EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.ATP-dependent chromatin remodeling: genetics, genomics and mechanisms.

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Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation

http://www.wikidata.org/entity/Q34213023

description

2010 nî lūn-bûn

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2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Epigenetic antagonism between ...... uring oncogenic transformation

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Epigenetic antagonism between ...... uring oncogenic transformation

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Epigenetic antagonism between ...... uring oncogenic transformation

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Epigenetic antagonism between ...... uring oncogenic transformation

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Epigenetic antagonism between ...... uring oncogenic transformation

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J.CCR.2010.09.006

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Epigenetic antagonism between ...... uring oncogenic transformation

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Boris G Wilson

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Charles W M Roberts

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Elizabeth S McKenna

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Scott L Pomeroy

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Stuart H Orkin

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Xi Wang

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Xiaohua Shen

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Yoon-Jae Cho

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2

Control of developmental regulators by Polycomb in human embryonic stem cells

The epigenomics of cancer

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression.

Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice

Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice

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316-328

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4

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18

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Madeleine Lemieux

Edward C. Koellhoffer

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2010-10-01T00:00:00Z

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47449242

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20951942

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2957473

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