Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.
about
Early Diagnosis of Werner's Syndrome Using Exome-Wide Sequencing in a Single, Atypical PatientSpectrum and risk of neoplasia in Werner syndrome: a systematic reviewThe Werner syndrome protein is distinguished from the Bloom syndrome protein by its capacity to tightly bind diverse DNA structuresWerner SyndromeWRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shorteningA unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifsNucleolar localization of the Werner syndrome protein in human cellsThe spectrum of WRN mutations in Werner syndrome patientsp53-mediated apoptosis is attenuated in Werner syndrome cellsMutator phenotype of Werner syndrome is characterized by extensive deletionsHuman RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biologyRoles of Werner syndrome protein in protection of genome integrityModel of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromesThe Bloom's syndrome gene product promotes branch migration of holliday junctionsHomologous Recombination and Its Role in CarcinogenesisA conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in ArabidopsisEvidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence.DNA Damage: A Main Determinant of Vascular AgingMechanisms of Origin, Phenotypic Effects and Diagnostic Implications of Complex Chromosome RearrangementsGenetics of primary ovarian insufficiency: new developments and opportunitiesSearch and insights into novel genetic alterations leading to classical and atypical Werner syndromeMetabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null MiceMPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage.Deletion of Ku86 causes early onset of senescence in miceEpigenetic inactivation of the premature aging Werner syndrome gene in human cancerThe Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δAssociation of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cellsWerner syndrome: Clinical features, pathogenesis and potential therapeutic interventionsSubstrate-specific inhibition of RecQ helicaseTelomere shortening exposes functions for the mouse Werner and Bloom syndrome genesA deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacityEosinophilic fasciitis. Case report and review of the literature.Mobility in the structure of E.coli recQ helicase upon substrate binding as seen from molecular dynamics simulations.The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci.Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest.Sequence-specific processing of telomeric 3' overhangs by the Werner syndrome protein exonuclease activityExpression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide.A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro.Mouse models of telomere dysfunction phenocopy skeletal changes found in human age-related osteoporosis.Waardenburg-like features with cataracts, small head size, joint abnormalities, hypogonadism, and osteosarcoma.
P2860
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P2860
Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.
description
1966 nî lūn-bûn
@nan
1966 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1966 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1966年の論文
@ja
1966年論文
@yue
1966年論文
@zh-hant
1966年論文
@zh-hk
1966年論文
@zh-mo
1966年論文
@zh-tw
1966年论文
@wuu
name
Werner's syndrome a review of ...... to the natural aging process.
@ast
Werner's syndrome a review of ...... to the natural aging process.
@en
Werner's syndrome a review of ...... to the natural aging process.
@nl
type
label
Werner's syndrome a review of ...... to the natural aging process.
@ast
Werner's syndrome a review of ...... to the natural aging process.
@en
Werner's syndrome a review of ...... to the natural aging process.
@nl
prefLabel
Werner's syndrome a review of ...... to the natural aging process.
@ast
Werner's syndrome a review of ...... to the natural aging process.
@en
Werner's syndrome a review of ...... to the natural aging process.
@nl
P2093
P1433
P1476
Werner's syndrome a review of ...... to the natural aging process.
@en
P2093
Epstein CJ
Motulsky AG
Schultz AL
P304
P407
P577
1966-05-01T00:00:00Z