The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors.
about
ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progressionInactivation of dual-specificity phosphatases is involved in the regulation of extracellular signal-regulated kinases by heat shock and hsp72p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinaseRas/Raf signalling and emerging pharmacotherapeutic targets.Targeting the Raf kinase cascade in cancer therapy--novel molecular targets and therapeutic strategies.Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in patients with advanced solid tumorsRaf kinases: function, regulation and role in human cancer.Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancerSynergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity.Clinical overview of sorafenib in breast cancer.Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen.Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells.Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation.Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family.Upregulation of MAPK pathway is associated with survival in castrate-resistant prostate cancer.Regulation of cell proliferation by autocrine motility factor/phosphoglucose isomerase signaling.[Resveratrol inhibits EGF-induced invasion of human lung adenocarcinoma A549 cells].Epidermal growth factor receptor (EGFR) downstream molecules as response predictive markers for gefitinib (Iressa, ZD1839) in chemotherapy-resistant non-small cell lung cancer.The MEK-ERK signaling pathway is a negative regulator of cartilage-specific gene expression in embryonic limb mesenchyme.
P2860
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P2860
The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The Raf signal transduction ca ...... owth factor-responsive tumors.
@ast
The Raf signal transduction ca ...... owth factor-responsive tumors.
@en
The Raf signal transduction ca ...... owth factor-responsive tumors.
@nl
type
label
The Raf signal transduction ca ...... owth factor-responsive tumors.
@ast
The Raf signal transduction ca ...... owth factor-responsive tumors.
@en
The Raf signal transduction ca ...... owth factor-responsive tumors.
@nl
prefLabel
The Raf signal transduction ca ...... owth factor-responsive tumors.
@ast
The Raf signal transduction ca ...... owth factor-responsive tumors.
@en
The Raf signal transduction ca ...... owth factor-responsive tumors.
@nl
P2093
P1476
The Raf signal transduction ca ...... owth factor-responsive tumors.
@en
P2093
Blalock WL
McCubrey JA
Steelman LS
Weinstein-Oppenheimer CR
P304
P356
10.1016/S0163-7258(00)00085-1
P577
2000-12-01T00:00:00Z