Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties
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Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor AntagonismA functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2Membrane driven spatial organization of GPCRs.Structure-based simulations reveal concerted dynamics of GPCR activationNot just an oil slick: how the energetics of protein-membrane interactions impacts the function and organization of transmembrane proteins.Ligand-dependent activation and deactivation of the human adenosine A(2A) receptor.A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain.Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation.AIM for Allostery: Using the Ising Model to Understand Information Processing and Transmission in Allosteric Biomolecular Systems.Why GPCRs behave differently in cubic and lamellar lipidic mesophases.A GIPC1-Palmitate Switch Modulates Dopamine Drd3 Receptor Trafficking and Signaling.The cost of living in the membrane: a case study of hydrophobic mismatch for the multi-segment protein LeuT.Cholesterol-dependent Conformational Plasticity in GPCR Dimers.The membrane protein LeuT in micellar systems: aggregation dynamics and detergent binding to the S2 site.Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.Molecular pharmacology and ligand docking studies reveal a single amino acid difference between mouse and human serotonin 5-HT2A receptors that impacts behavioral translation of novel 4-phenyl-2-dimethylaminotetralin ligandsGraded activation and free energy landscapes of a muscarinic G-protein-coupled receptor.Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamicsProgress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists.G-protein coupled receptors: advances in simulation and drug discovery.Computational Insights into the Mechanism of Inhibition of OASS-A by a Small Molecule Inhibitor.Differential dynamics of the serotonin1A receptor in membrane bilayers of varying cholesterol content revealed by all atom molecular dynamics simulation.Lipid interaction sites on channels, transporters and receptors: Recent insights from molecular dynamics simulations.Structural conservation among the rhodopsin-like and other G protein-coupled receptors.Structural features of the regulatory ACT domain of phenylalanine hydroxylase.Cholesterol-β1 AR interaction versus cholesterol-β2 AR interaction.Putative cholesterol-binding sites in human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5.Antioxidant and Membrane Binding Properties of Serotonin Protect Lipids from Oxidation.Molecular modeling studies give hint for the existence of a symmetric hβ₂R-Gαβγ-homodimer.Membrane cholesterol effect on the 5-HT2A receptor: Insights into the lipid-induced modulation of an antipsychotic drug target.Conformational restriction of G-proteins Coupled Receptors (GPCRs) upon complexation to G-proteins: a putative activation mode of GPCRs?Beta2-adrenergic receptor homodimers: Role of transmembrane domain 1 and helix 8 in dimerization and cell surface expression.Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor.Mechanism of the G-protein mimetic nanobody binding to a muscarinic G-protein-coupled receptor.
P2860
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P2860
Ligand-dependent conformations and dynamics of the serotonin 5-HT(2A) receptor determine its activation and membrane-driven oligomerization properties
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Ligand-dependent conformations and dynamics of the serotonin 5-HT
@nl
Ligand-dependent conformations ...... ven oligomerization properties
@ast
Ligand-dependent conformations ...... ven oligomerization properties
@en
type
label
Ligand-dependent conformations and dynamics of the serotonin 5-HT
@nl
Ligand-dependent conformations ...... ven oligomerization properties
@ast
Ligand-dependent conformations ...... ven oligomerization properties
@en
prefLabel
Ligand-dependent conformations and dynamics of the serotonin 5-HT
@nl
Ligand-dependent conformations ...... ven oligomerization properties
@ast
Ligand-dependent conformations ...... ven oligomerization properties
@en
P2093
P2860
P1476
Ligand-dependent conformations ...... ven oligomerization properties
@en
P2093
Ernest L Mehler
George Khelashvili
Jufang Shan
P2860
P304
P356
10.1371/JOURNAL.PCBI.1002473
P577
2012-04-19T00:00:00Z