Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation. - Wikidata - awgldk - TriplyDB

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

http://www.wikidata.org/entity/Q34246700

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Modulating splicing with small molecular inhibitors of the spliceosome Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression Structural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density maps Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Inhibition of U4 snRNA in human cells causes the stable retention of polyadenylated pre-mRNA in the nucleus.Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives Psoromic acid derivatives: a new family of small-molecule pre-mRNA splicing inhibitors discovered by a stage-specific high-throughput in vitro splicing assay.Rearrangements within human spliceosomes captured after exon ligation.Mechanisms and Regulation of Alternative Pre-mRNA Splicing The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region.Real-time imaging of cotranscriptional splicing reveals a kinetic model that reduces noise: implications for alternative splicing regulation Limiting of the innate immune response by SF3A-dependent control of MyD88 alternative mRNA splicing.Pre-mRNA splicing is a determinant of histone H3K36 methylation Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor.Identification of small molecule inhibitors of pre-mRNA splicing.The Natural Product N-Palmitoyl-l-leucine Selectively Inhibits Late Assembly of Human Spliceosomes The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B Nuclear cyclophilins affect spliceosome assembly and function in vitro.Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.Small Molecule Modulators of Pre-mRNA Splicing in Cancer Therapy Ruthenium-Catalyzed Olefin Metathesis after Tetra-n-butylammonium Fluoride-Mediated Desilylation.Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages The in vivo dynamics of TCERG1, a factor that couples transcriptional elongation with splicing Live-cell visualization of pre-mRNA splicing with single-molecule sensitivity.Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs.Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene An active role for splicing in 3'-end formation.Herboxidiene biosynthesis, production, and structural modifications: prospect for hybrids with related polyketide.Modulation of alternative splicing by anticancer drugs.Diverse regulation of 3' splice site usage.Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.Interplay between pre-mRNA splicing and microRNA biogenesis within the supraspliceosome.Therapeutic targeting of splicing in cancer.Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.Sudemycin E influences alternative splicing and changes chromatin modifications.The role of RNA alternative splicing in regulating cancer metabolism.

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P2860

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

http://www.wikidata.org/entity/Q34246700

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年学术文章

@wuu

2010年学术文章

@zh-cn

2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@ast

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@en

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@nl

type

label

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@ast

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@en

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@nl

prefLabel

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@ast

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@en

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@nl

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P1433

Nucleic Acids Research

P1476

Spliceostatin A inhibits spliceosome assembly subsequent to prespliceosome formation.

@en

P2093

Gabriel A Roybal

http://www.w3.org/2001/XMLSchema#string

Melissa S Jurica

http://www.w3.org/2001/XMLSchema#string

P2860

Functional association of U2 snRNP with the ATP-independent spliceosomal complex E

Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A

A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site

Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA

A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction

The spliceosome: design principles of a dynamic RNP machine

Small-molecule inhibition of HIV pre-mRNA splicing as a novel antiretroviral therapy to overcome drug resistance

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein

RNA and disease

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

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6664-6672

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scholarly article

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10.1093/NAR/GKQ494

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19

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38

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2010-06-06T00:00:00Z

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44655632

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20529876

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2965229

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