HIV integrase, a brief overview from chemistry to therapeutics.
about
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cellsHuman Pso4 is a metnase (SETMAR)-binding partner that regulates metnase function in DNA repairTransient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virusHIV-1 integrase crosslinked oligomers are active in vitroBiochemical characterization of a SET and transposase fusion protein, Metnase: its DNA binding and DNA cleavage activityStructure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.Crystal structures of catalytic core domain of BIV integrase: implications for the interaction between integrase and target DNAStacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activityRobust optimization of SVM hyperparameters in the classification of bioactive compoundsHIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cellsIdentification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integraseLEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactorsMeasuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domainEfficient and specific internal cleavage of a retroviral palindromic DNA sequence by tetrameric HIV-1 integrase.An unusual helix turn helix motif in the catalytic core of HIV-1 integrase binds viral DNA and LEDGF.A nonradioactive plate-based assay for stimulators of nonspecific DNA nicking by HIV-1 integrase and other nucleases.An interlocked dimeric parallel-stranded DNA quadruplex: a potent inhibitor of HIV-1 integrase.Solution conformation and dynamics of the HIV-1 integrase core domain.Effect of HIV integrase inhibitors on the RAG1/2 recombinase.Evaluation of a system to screen for stimulators of non-specific DNA nicking by HIV-1 integrase: application to a library of 50,000 compounds.Peptides that inhibit HIV-1 integrase by blocking its protein-protein interactions.Regulatory mechanisms by which barrier-to-autointegration factor blocks autointegration and stimulates intermolecular integration of Moloney murine leukemia virus preintegration complexes.In vitro evolution of an HIV integrase binding protein from a library of C-terminal domain γS-crystallin variants.Directed DNA shuffling of retrovirus and retrotransposon integrase protein domainsStereoselective synthesis of a model C(18)-C(35) spiroketal fragment of integramycinIntegration by design.Integrating prokaryotes and eukaryotes: DNA transposases in light of structure.Extended use of raltegravir in the treatment of HIV-1 infection: optimizing therapyImpairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect.Chromosomal integration of LTR-flanked DNA in yeast expressing HIV-1 integrase: down regulation by RAD51.Inhibiting HIV-1 integrase by shifting its oligomerization equilibriumRing substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1The removal of RNA primers from DNA synthesized by the reverse transcriptase of the retrotransposon Tf1 is stimulated by Tf1 integraseRole of host-encoded proteins in restriction of retroviral integration.Alternative nucleophilic substrates for the endonuclease activities of human immunodeficiency virus type 1 integraseThe role of lysine 186 in HIV-1 integrase multimerizationLack of integrase inhibitors associated resistance mutations among HIV-1C isolates.Raltegravir: first in class HIV integrase inhibitor.Integrase, LEDGF/p75 and HIV replication.Structural and functional insights into foamy viral integrase
P2860
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P2860
HIV integrase, a brief overview from chemistry to therapeutics.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
HIV integrase, a brief overview from chemistry to therapeutics.
@ast
HIV integrase, a brief overview from chemistry to therapeutics.
@en
HIV integrase, a brief overview from chemistry to therapeutics.
@nl
type
label
HIV integrase, a brief overview from chemistry to therapeutics.
@ast
HIV integrase, a brief overview from chemistry to therapeutics.
@en
HIV integrase, a brief overview from chemistry to therapeutics.
@nl
prefLabel
HIV integrase, a brief overview from chemistry to therapeutics.
@ast
HIV integrase, a brief overview from chemistry to therapeutics.
@en
HIV integrase, a brief overview from chemistry to therapeutics.
@nl
P2860
P356
P1476
HIV integrase, a brief overview from chemistry to therapeutics.
@en
P2093
P2860
P304
23213-23216
P356
10.1074/JBC.R100027200
P407
P577
2001-05-09T00:00:00Z