LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors - Wikidata - awgldk - TriplyDB

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

http://www.wikidata.org/entity/Q28475761

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HIVToolbox, an integrated web application for investigating HIV p12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomes Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for efficient in vitro integration into stable nucleosomes LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Targeting HIV-1 DNA integration by swapping tethers Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse.Molecular mechanisms of retroviral integration site selection.Transcriptional provirus silencing as a crosstalk of de novo DNA methylation and epigenomic features at the integration site Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses.Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant.TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection.Retroviral integration site selection.Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites.LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication The effects of cocaine on HIV transcription The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.Novel integrase inhibitors for HIV.The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights Epigenetic regulation of HIV-1 transcription.HIV latency.Feline immunodeficiency virus envelope glycoproteins antagonize tetherin through a distinctive mechanism that requires virion incorporation.TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism.Alteration of select gene expression patterns in individuals infected with HIV-1.HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin.Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase.LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends.Proviruses selected for high and stable expression of transduced genes accumulate in broadly transcribed genome areas.rDNA-directed integration by an HIV-1 integrase--I-PpoI fusion protein Cellular and molecular mechanisms of HIV-1 integration targeting.

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LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

http://www.wikidata.org/entity/Q28475761

description

2009 nî lūn-bûn

@nan

2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@ast

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@en

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@nl

type

label

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@ast

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@en

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@nl

prefLabel

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@ast

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@en

LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@nl

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JOURNAL.PPAT.1000522

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LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors

@en

P2093

Anne M Meehan

http://www.w3.org/2001/XMLSchema#string

Dyana T Saenz

http://www.w3.org/2001/XMLSchema#string

Eric M Poeschla

http://www.w3.org/2001/XMLSchema#string

James H Morrison

http://www.w3.org/2001/XMLSchema#string

Jose A Garcia-Rivera

http://www.w3.org/2001/XMLSchema#string

Manuel Llano

http://www.w3.org/2001/XMLSchema#string

Mary Peretz

http://www.w3.org/2001/XMLSchema#string

P2860

Initial sequencing and analysis of the human genome

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

Large-scale identification of mammalian proteins localized to nuclear sub-compartments

H1 family histones in the nucleus. Control of binding and localization by the C-terminal domain

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo

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e1000522

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scholarly article

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10.1371/JOURNAL.PPAT.1000522

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7

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5

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2009-07-01T00:00:00Z

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26677136

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19609362

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2706977

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