Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.
about
Out of balance: R-loops in human diseaseGenome instability and transcription elongation impairment in human cells depleted of THO/TREXHuman hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.Recruitment of the human TREX complex to mRNA during splicingHuman 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sitesNew insights into repeat instability: role of RNA•DNA hybridsCancer cells and normal cells differ in their requirements for Thoc1Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaksEukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domainA network of multi-tasking proteins at the DNA replication fork preserves genome stabilityCoordinate enhancement of transgene transcription and translation in a lentiviral vectorDecoding mechanisms by which silent codon changes influence protein biogenesis and functionBreaking bad: R-loops and genome integrityMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeSources of DNA double-strand breaks and models of recombinational DNA repairThe Caenorhabditis elegans THO complex is required for the mitotic cell cycle and developmentRNase H2 roles in genome integrity revealed by unlinking its activitiesAID targeting is dependent on RNA polymerase II pausing.The THO complex component Thp2 counteracts telomeric R-loops and telomere shorteningAn endoribonuclease functionally linked to perinuclear mRNP quality control associates with the nuclear pore complexesA new connection of mRNP biogenesis and export with transcription-coupled repairTho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutantsAn hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination.Swt1, a novel yeast protein, functions in transcription.Dissecting mechanisms of nuclear mRNA surveillance in THO/sub2 complex mutants.R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity.The Transcription Factor THO Promotes Transcription Initiation and Elongation by RNA Polymerase I.Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA exportThe yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein.Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes.Cotranscriptional recruitment of the serine-arginine-rich (SR)-like proteins Gbp2 and Hrb1 to nascent mRNA via the TREX complex.Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery.RNA-templated DNA repairNew suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation.The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.The role of TREX in gene expression and diseaseReplication stress in Mammalian cells and its consequences for mitosisRNA Exosome Regulates AID DNA Mutator Activity in the B Cell GenomeThe Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase
P2860
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P2860
Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Cotranscriptionally formed DNA ...... tion-associated recombination.
@ast
Cotranscriptionally formed DNA ...... tion-associated recombination.
@en
Cotranscriptionally formed DNA ...... tion-associated recombination.
@nl
type
label
Cotranscriptionally formed DNA ...... tion-associated recombination.
@ast
Cotranscriptionally formed DNA ...... tion-associated recombination.
@en
Cotranscriptionally formed DNA ...... tion-associated recombination.
@nl
prefLabel
Cotranscriptionally formed DNA ...... tion-associated recombination.
@ast
Cotranscriptionally formed DNA ...... tion-associated recombination.
@en
Cotranscriptionally formed DNA ...... tion-associated recombination.
@nl
P1433
P1476
Cotranscriptionally formed DNA ...... tion-associated recombination.
@en
P304
P356
10.1016/J.MOLCEL.2003.08.010
P577
2003-09-01T00:00:00Z