Biological activities and potential molecular targets of cucurbitacins: a focus on cancer.
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Cucurbitacins - a promising target for cancer therapyCucurbitacin E induces cell cycle G2/M phase arrest and apoptosis in triple negative breast cancerIn vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin BCucurbitacin I Attenuates Cardiomyocyte Hypertrophy via Inhibition of Connective Tissue Growth Factor (CCN2) and TGF- β/Smads SignalingsInducement of apoptosis by cucurbitacin E, a tetracyclic triterpenes, through death receptor 5 in human cervical cancer cell lines.Convergence and divergence of bitterness biosynthesis and regulation in CucurbitaceaeCucurbitacin E reduces obesity and related metabolic dysfunction in mice by targeting JAK-STAT5 signaling pathway.Plant science. Biosynthesis, regulation, and domestication of bitterness in cucumber.Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad.Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.Cucurbitacin IIb exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes.VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formationCucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity.Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells.An updated review of Cucurbitacins and their biological and pharmacological activities.Growth inhibitory effect of Cucurbitacin E on breast cancer cells.Cucurbitacin E as inducer of cell death and apoptosis in human oral squamous cell carcinoma cell line SASCucurbitacin E inhibits osteosarcoma cells proliferation and invasion through attenuation of PI3K/AKT/mTOR signaling.Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer.Inducement of mitosis delay by cucurbitacin E, a novel tetracyclic triterpene from climbing stem of Cucumis melo L., through GADD45γ in human brain malignant glioma (GBM) 8401 cells.Therapeutic ROS targeting of GADD45γ in the induction of G2/M arrest in primary human colorectal cancer cell lines by cucurbitacin E.Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro.Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells.Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549.Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B.Structural optimization and biological screening of a steroidal scaffold possessing cucurbitacin-like functionalities as B-Raf inhibitors.Formation of cofilin-actin rods following cucurbitacin-B-induced actin aggregation depends on Slingshot homolog 1-mediated cofilin hyperactivation.Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophages.Cucurbitacins: elucidation of their interactions with the cytoskeleton.ANTITUMOR AND APOPTOTIC EFFECTS OF CUCURBITACIN A IN A-549 LUNG CARCINOMA CELLS IS MEDIATED VIA G2/M CELL CYCLE ARREST AND M-TOR/PI3K/AKT SIGNALLING PATHWAY.Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary targetCucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells.Cucurbitacin-B attenuates CCl4 -induced hepatic fibrosis in mice through inhibition of STAT-3.Biological screening of cucurbitacin inspired estrone analogs targeting mitogen-activated protein kinase (MAPK) pathway.Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells.Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery.Modified mixed nanomicelles with collagen peptides enhanced oral absorption of Cucurbitacin B: preparation and evaluation.Ethanol enhances cucurbitacin B-induced apoptosis by inhibiting cucurbitacin B-induced autophagy in LO2 hepatocytesCucurbitacin E Inhibits Proliferation and Migration of Intestinal Epithelial Cells via Activating Cofilin
P2860
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P2860
Biological activities and potential molecular targets of cucurbitacins: a focus on cancer.
description
2012 nî lūn-bûn
@nan
2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Biological activities and pote ...... rbitacins: a focus on cancer.
@ast
Biological activities and pote ...... rbitacins: a focus on cancer.
@en
Biological activities and pote ...... rbitacins: a focus on cancer.
@nl
type
label
Biological activities and pote ...... rbitacins: a focus on cancer.
@ast
Biological activities and pote ...... rbitacins: a focus on cancer.
@en
Biological activities and pote ...... rbitacins: a focus on cancer.
@nl
prefLabel
Biological activities and pote ...... rbitacins: a focus on cancer.
@ast
Biological activities and pote ...... rbitacins: a focus on cancer.
@en
Biological activities and pote ...... rbitacins: a focus on cancer.
@nl
P2093
P1433
P1476
Biological activities and pote ...... rbitacins: a focus on cancer.
@en
P2093
Jiajie Guo
Jiaolin Bao
Mingqing Huang
Xiuping Chen
Yitao Wang
P304
P356
10.1097/CAD.0B013E3283541384
P50
P577
2012-09-01T00:00:00Z