Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept.
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The molecular mechanism of the inhibition by licofelone of the biosynthesis of 5-lipoxygenase productsThe effect of single-dose naproxen on eicosanoid formation in human gastroduodenal mucosaNovel paradigms for drug discovery: computational multitarget screeningStructural Examination of 6-Methylsulphonylphenanthro- [9,10-C]-furan-1(3H)-one-A Rofecoxib Degradation Product.Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1)Is licofelone, a dual inhibitor of cyclo-oxygenase and 5-lipoxygenase, a promising alternative in anti-inflammatory therapy?In Silico Analysis of the Potential of the Active Compounds Fucoidan and Alginate Derived from Sargassum Sp. as Inhibitors of COX-1 and COX-2Pain management for dentists: the role of ibuprofen.The Gastroprotective Role of Acanthus ilicifolius - A Study to Unravel the Underlying Mechanism of Anti-Ulcer Activity.Gastrointestinal toxicity among patients taking selective COX-2 inhibitors or conventional NSAIDs, alone or combined with proton pump inhibitors: a case-control study.Novel mechanisms of nonsteroidal anti-inflammatory drug-induced renal toxicity.The Development of Novel Therapies for Rheumatoid ArthritisThe classical vs nonclassical NSAIDs: can the reduction in pain overcome the thrombotic risk?Activity and potential role of licofelone in the management of osteoarthritis.Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages.Renal adverse effects of nonsteroidal anti-inflammatory drugs.5-Lipoxygenase inhibitors: a review of recent developments and patents.Omega-3 polyunsaturated fatty acids as an angelus custos to rescue patients from NSAID-induced gastroduodenal damage.The inhibitory activity of cocoa phenolic extract against pro-inflammatory mediators secretion induced by lipopolysaccharide in RAW 264.7 cellsCarnosol and carnosic acids from Salvia officinalis inhibit microsomal prostaglandin E2 synthase-1.Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1Atrovirinone inhibits pro-inflammatory mediator release from murine macrophages and human whole blood.Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase.Synthesis, analgesic and anti-inflammatory activities of new methyl-imidazolyl-1,3,4-oxadiazoles and 1,2,4-triazoles.Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis.Grand challenges in pharmacotherapy of inflammation for the first decades of the 21st century.Combination Therapy of PPARgamma Ligands and Inhibitors of Arachidonic Acid in Lung CancerThe regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 MAP kinase signalling pathway.Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP.The gastrointestinal tolerability of the LOX/COX inhibitor, licofelone, is similar to placebo and superior to naproxen therapy in healthy volunteers: results from a randomized, controlled trial.Ligand-based Modeling for the Prediction of Pharmacophore Features for Multi-targeted Inhibition of the Arachidonic Acid Cascade.
P2860
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P2860
Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@ast
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@en
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@nl
type
label
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@ast
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@en
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@nl
prefLabel
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@ast
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@en
Anti-inflammatory drugs: new m ...... . The dual inhibition concept.
@nl
P356
P1476
Anti-inflammatory drugs: new m ...... m. The dual inhibition concept
@en
P2093
P304
P356
10.1006/PHRS.2000.0784
P577
2001-05-01T00:00:00Z