Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases.
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LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interactionA clogged gutter mechanism for protease inhibitors.Predicting binding energetics from structure: looking beyond DeltaG degrees.A stochastic algorithm for global optimization and for best populations: a test case of side chains in proteins.Selection of human elastase inhibitors from a conformationally constrained combinatorial peptide library.Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues.Heparin enhances the specificity of antithrombin for thrombin and factor Xa independent of the reactive center loop sequence. Evidence for an exosite determinant of factor Xa specificity in heparin-activated antithrombin.Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1.Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes.A preference-based free-energy parameterization of enzyme-inhibitor binding. Applications to HIV-1-protease inhibitor designAdditivity-based design of the strongest possible turkey ovomucoid third domain inhibitors for porcine pancreatic elastase (PPE) and Streptomyces griseus protease B (SGPB).Analysis of serine proteinase-inhibitor interaction by alanine shaving.Stable monomeric form of an originally dimeric serine proteinase inhibitor, ecotin, was constructed via site directed mutagenesis.Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications.SERINE proteinase like activity in apolipophorin III from the hemolymph of desert locust, Schistocerca gregaria.Characterization of carbohydrate chains of C1-inhibitor and of desialylated C1-inhibitor.SKEMPI: a Structural Kinetic and Energetic database of Mutant Protein Interactions and its use in empirical models.Experimental results from host-guest complexes for the design of effectors in biological systems and of enzyme analogous catalysts.Binding of amino acid side chains to preformed cavities: interaction of serine proteinases with turkey ovomucoid third domains with coded and noncoded P1 residues.Calculation of the free energy of association for protein complexesCrystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.Pancreatic secretory trypsin inhibitor acts as an effective inhibitor of cysteine proteinases gingipains from Porphyromonas gingivalis.Sequences encoding two trypsin inhibitors occur in strikingly similar genomic environments.Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis.Analogues of trypsin inhibitor SFTI-1 modified in the conserved P₁' position by synthetic or non-proteinogenic amino acids retain their inhibitory activity.Selenopeptide analogs of EETI-II retain potent trypsin inhibitory activities.Examples of peptide-peptoid hybrid serine protease inhibitors based on the trypsin inhibitor SFTI-1 with complete protease resistance at the P1-P1' reactive site.Inhibitory activity of double-sequence analogues of trypsin inhibitor SFTI-1 from sunflower seeds: an example of peptide splicing.Total chemical synthesis of bovine pancreatic trypsin inhibitor by native chemical ligation.Ionizable P1 residues in serine proteinase inhibitors undergo large pK shifts on complex formation.Primary structure and properties of the cathepsin G/chymotrypsin inhibitor from the larval hemolymph of Apis mellifera.Alteration of the specificity of ecotin, an E. coli serine proteinase inhibitor, by site directed mutagenesis.Does the Kunitz domain from the Alzheimer's amyloid beta protein precursor inhibit a kallikrein responsible for post-translational processing of nerve growth factor precursor?Binding of the Bovine and Porcine Pancreatic Secretory Trypsin Inhibitor (Kazal) To Human Leukocyte Elastase: A Thermodynamic StudyCharacterization of potato proteinase inhibitor II reactive site mutants
P2860
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P2860
Thermodynamics and kinetics of single residue replacements in avian ovomucoid third domains: effect on inhibitor interactions with serine proteinases.
description
1982 nî lūn-bûn
@nan
1982 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1982 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1982年の論文
@ja
1982年論文
@yue
1982年論文
@zh-hant
1982年論文
@zh-hk
1982年論文
@zh-mo
1982年論文
@zh-tw
1982年论文
@wuu
name
Thermodynamics and kinetics of ...... tions with serine proteinases.
@ast
Thermodynamics and kinetics of ...... tions with serine proteinases.
@en
Thermodynamics and kinetics of ...... tions with serine proteinases.
@nl
type
label
Thermodynamics and kinetics of ...... tions with serine proteinases.
@ast
Thermodynamics and kinetics of ...... tions with serine proteinases.
@en
Thermodynamics and kinetics of ...... tions with serine proteinases.
@nl
prefLabel
Thermodynamics and kinetics of ...... tions with serine proteinases.
@ast
Thermodynamics and kinetics of ...... tions with serine proteinases.
@en
Thermodynamics and kinetics of ...... tions with serine proteinases.
@nl
P356
P1433
P1476
Thermodynamics and kinetics of ...... tions with serine proteinases.
@en
P2093
Laskowski M Jr
P304
P356
10.1021/BI00539A002
P407
P577
1982-05-01T00:00:00Z