Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter
about
Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivityRegulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domainsNovel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeThe Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome SystemTNF-alpha-mediated apoptosis in vascular smooth muscle cells requires p73Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expressionp73 as a pharmaceutical target for cancer therapydeltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivoFunction of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation.Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells.TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Ethyl acetate fraction from Cudrania tricuspidata inhibits IL-1beta-stimulated osteoclast differentiation through downregulation of MAPKs, c-Fos and NFATc1The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function.Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.p63 and p73, the ancestors of p53.TAp73 and ΔNp73 have opposing roles in 5-aza-2'-deoxycytidine-induced apoptosis in breast cancer cells.Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors.The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice.Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cellsEthyl acetate fraction from Angelica sinensis inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production.Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer.ΔNp73 enhances promoter activity of TGF-β induced genes.Proinflammatory cytokines and bile acids upregulate ΔNp73 protein, an inhibitor of p53 and p73 tumor suppressors.TP53 family members and human cancers.Ubiquitin and ubiquitin-like modifications of the p53 family.p73 in Cancer.p53 Family: Role of Protein Isoforms in Human Cancer.p53 and p73 display common and distinct requirements for sequence specific binding to DNAp73, a sophisticated p53 family member in the cancer world.DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors.UBE4B: a promising regulatory molecule in neuronal death and survival.Prognostic value of increase in transcript levels of Tp73 DeltaEx2-3 isoforms in low-grade glioma patients.TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function.p73alpha isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cellsRNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant DefenseTherapeutic prospects for p73 and p63: rising from the shadow of p53.Mechanisms, function and clinical applications of DNp73.
P2860
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P2860
Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@ast
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@en
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@nl
type
label
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@ast
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@en
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@nl
prefLabel
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@ast
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@en
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@nl
P2093
P2860
P1476
Autoinhibitory regulation of p ...... within the Delta Np73 promoter
@en
P2093
Akira Nakagawara
Hiroyuki Mizuguchi
Ken-ichi Watanabe Ki
Masato Takahashi
Satoru Todo
Takahito Nakagawa
Takao Hayakawa
Toshinori Ozaki
P2860
P304
P356
10.1128/MCB.22.8.2575-2585.2002
P407
P577
2002-04-01T00:00:00Z