Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter - Wikidata - awgldk - TriplyDB

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

http://www.wikidata.org/entity/Q34277205

about

Runt-related transcription factor 2 attenuates the transcriptional activity as well as DNA damage-mediated induction of pro-apoptotic TAp73 to regulate chemosensitivity Regulation of the MiTF/TFE bHLH-LZ transcription factors through restricted spatial expression and alternative splicing of functional domains Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 Transactivation specificity is conserved among p53 family proteins and depends on a response element sequence code The Regulation of Tumor Suppressor p63 by the Ubiquitin-Proteasome System TNF-alpha-mediated apoptosis in vascular smooth muscle cells requires p73 Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression p73 as a pharmaceutical target for cancer therapy deltaNp73 facilitates cell immortalization and cooperates with oncogenic Ras in cellular transformation in vivo Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation.Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells.TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.Ethyl acetate fraction from Cudrania tricuspidata inhibits IL-1beta-stimulated osteoclast differentiation through downregulation of MAPKs, c-Fos and NFATc1 The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function.Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.p63 and p73, the ancestors of p53.TAp73 and ΔNp73 have opposing roles in 5-aza-2'-deoxycytidine-induced apoptosis in breast cancer cells.Characterization of ΔNp73 expression and regulation in gastric and esophageal tumors.The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice.Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells Ethyl acetate fraction from Angelica sinensis inhibits IL-1β-induced rheumatoid synovial fibroblast proliferation and COX-2, PGE2, and MMPs production.Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer.ΔNp73 enhances promoter activity of TGF-β induced genes.Proinflammatory cytokines and bile acids upregulate ΔNp73 protein, an inhibitor of p53 and p73 tumor suppressors.TP53 family members and human cancers.Ubiquitin and ubiquitin-like modifications of the p53 family.p73 in Cancer.p53 Family: Role of Protein Isoforms in Human Cancer.p53 and p73 display common and distinct requirements for sequence specific binding to DNA p73, a sophisticated p53 family member in the cancer world.DeltaNp73, a dominant-negative inhibitor of wild-type p53 and TAp73, is up-regulated in human tumors.UBE4B: a promising regulatory molecule in neuronal death and survival.Prognostic value of increase in transcript levels of Tp73 DeltaEx2-3 isoforms in low-grade glioma patients.TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function.p73alpha isoforms drive opposite transcriptional and post-transcriptional regulation of MYCN expression in neuroblastoma cells RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense Therapeutic prospects for p73 and p63: rising from the shadow of p53.Mechanisms, function and clinical applications of DNp73.

P2860

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P2860

Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter

http://www.wikidata.org/entity/Q34277205

description

2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Autoinhibitory regulation of p ...... within the Delta Np73 promoter

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Autoinhibitory regulation of p ...... within the Delta Np73 promoter

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Autoinhibitory regulation of p ...... within the Delta Np73 promoter

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type

label

Autoinhibitory regulation of p ...... within the Delta Np73 promoter

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Autoinhibitory regulation of p ...... within the Delta Np73 promoter

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Autoinhibitory regulation of p ...... within the Delta Np73 promoter

@nl

prefLabel

Autoinhibitory regulation of p ...... within the Delta Np73 promoter

@ast

Autoinhibitory regulation of p ...... within the Delta Np73 promoter

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Autoinhibitory regulation of p ...... within the Delta Np73 promoter

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MCB.22.8.2575-2585.2002

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Molecular and Cellular Biology

P1476

Autoinhibitory regulation of p ...... within the Delta Np73 promoter

@en

P2093

Akira Nakagawara

http://www.w3.org/2001/XMLSchema#string

Hiroyuki Mizuguchi

http://www.w3.org/2001/XMLSchema#string

Ken-ichi Watanabe Ki

http://www.w3.org/2001/XMLSchema#string

Masato Takahashi

http://www.w3.org/2001/XMLSchema#string

Satoru Todo

http://www.w3.org/2001/XMLSchema#string

Takahito Nakagawa

http://www.w3.org/2001/XMLSchema#string

Takao Hayakawa

http://www.w3.org/2001/XMLSchema#string

Toshinori Ozaki

http://www.w3.org/2001/XMLSchema#string

P2860

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

Mdm2 promotes the rapid degradation of p53

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

ZBP-89 promotes growth arrest through stabilization of p53

MDM2 suppresses p73 function without promoting p73 degradation

A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3

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2575-2585

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scholarly article

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10.1128/MCB.22.8.2575-2585.2002

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8

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22

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2002-04-01T00:00:00Z

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11909952

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133713

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