Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.
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Dengue virus utilizes a novel strategy for translation initiation when cap-dependent translation is inhibitedThe C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationThe serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitorInvolvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta-cells.The eIF4E/eIF4G interaction inhibitor 4EGI-1 augments TRAIL-mediated apoptosis through c-FLIP Down-regulation and DR5 induction independent of inhibition of cap-dependent protein translationStarvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.KHDC1A, a novel translational repressor, induces endoplasmic reticulum-dependent apoptosisPI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.Targeting the eIF4F translation initiation complex: a critical nexus for cancer developmentRapid turnover of mcl-1 couples translation to cell survival and apoptosis.Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymesInhibitors of the mammalian target of rapamycin.Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytesRapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translationMitotic protein kinase CDK1 phosphorylation of mRNA translation regulator 4E-BP1 Ser83 may contribute to cell transformationNormalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?Gene expression profiling of HGF/Met activation in neonatal mouse heart.Phosphoproteomic analyses of L-02 liver cells exposed to trichloroethylene.Developing anti-neoplastic biotherapeutics against eIF4F.Role of the eIF4E binding protein 4E-BP1 in regulation of the sensitivity of human pancreatic cancer cells to TRAIL and celastrol-induced apoptosis.Cap-dependent mRNA translation and the ubiquitin-proteasome system cooperate to promote ERBB2-dependent esophageal cancer phenotype.Activation of p53 stimulates proteasome-dependent truncation of eIF4E-binding protein 1 (4E-BP1).Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism.Restoration of functional gap junctions through internal ribosome entry site-dependent synthesis of endogenous connexins in density-inhibited cancer cellsActivated eIF4E-binding protein slows G1 progression and blocks transformation by c-myc without inhibiting cell growth.Distinct regulation of internal ribosome entry site-mediated translation following cellular stress is mediated by apoptotic fragments of eIF4G translation initiation factor family members eIF4GI and p97/DAP5/NAT1.Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.Convallaria keiskei as a novel therapeutic alternative for salivary gland cancer treatment by targeting myeloid cell leukemia-1.ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death.The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemiaEffects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival.Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis.Understanding and Targeting the Eukaryotic Translation Initiation Factor eIF4E in Head and Neck Cancer.Participation of eIF4F complex in Junin virus infection: blockage of eIF4E does not impair virus replication.M-CSF, TNFalpha and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase.
P2860
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P2860
Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Translational control of cell ...... erns its proapoptotic potency.
@ast
Translational control of cell ...... erns its proapoptotic potency.
@en
Translational control of cell ...... erns its proapoptotic potency.
@nl
type
label
Translational control of cell ...... erns its proapoptotic potency.
@ast
Translational control of cell ...... erns its proapoptotic potency.
@en
Translational control of cell ...... erns its proapoptotic potency.
@nl
prefLabel
Translational control of cell ...... erns its proapoptotic potency.
@ast
Translational control of cell ...... erns its proapoptotic potency.
@en
Translational control of cell ...... erns its proapoptotic potency.
@nl
P2093
P2860
P50
P1476
Translational control of cell ...... erns its proapoptotic potency.
@en
P2093
Mark Peterson
Svetlana Avdulov
Vitaly A Polunovsky
P2860
P304
P356
10.1128/MCB.22.8.2853-2861.2002
P407
P577
2002-04-01T00:00:00Z