Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase
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Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in ArtemisDistinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaksStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Mapping and Quantitation of the Interaction between the Recombination Activating Gene Proteins RAG1 and RAG2.A hypomorphic recombination-activating gene 1 (RAG1) mutation resulting in a phenotype resembling common variable immunodeficiency.Crystal structure of the V(D)J recombinase RAG1-RAG2Molecular analysis of T-B-NK+ severe combined immunodeficiency and Omenn syndrome cases in Saudi ArabiaNon-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Artemis: guarding small children and, now, the genomeOverlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Requirements for DNA hairpin formation by RAG1/2DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.The bounty of RAGs: recombination signal complexes and reaction outcomes.V(D)J recombination: how to tame a transposase.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repairEvidence for Ku70/Ku80 association with full-length RAG1.Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restrictionLeaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.RAG: a recombinase diversified.Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.Molecular mechanism underlying RAG1/RAG2 synaptic complex formation.A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity.Mixing active-site components: a recipe for the unique enzymatic activity of a telomere resolvase.The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers.The central domain of core RAG1 preferentially recognizes single-stranded recombination signal sequence heptamer.Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.In vitro processing of the 3'-overhanging DNA in the postcleavage complex involved in V(D)J joining.T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes.Amino acid residues in Rag1 crucial for DNA hairpin formation.Molecular architecture of a eukaryotic DNA transposase.Transposition of hAT elements links transposable elements and V(D)J recombination.The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast.Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase
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P2860
Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase
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2002 nî lūn-bûn
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2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mutational analysis of all con ...... tants in the V(D)J recombinase
@ast
Mutational analysis of all con ...... tants in the V(D)J recombinase
@en
Mutational analysis of all con ...... tants in the V(D)J recombinase
@nl
type
label
Mutational analysis of all con ...... tants in the V(D)J recombinase
@ast
Mutational analysis of all con ...... tants in the V(D)J recombinase
@en
Mutational analysis of all con ...... tants in the V(D)J recombinase
@nl
prefLabel
Mutational analysis of all con ...... tants in the V(D)J recombinase
@ast
Mutational analysis of all con ...... tants in the V(D)J recombinase
@en
Mutational analysis of all con ...... tants in the V(D)J recombinase
@nl
P2093
P2860
P1476
Mutational analysis of all con ...... tants in the V(D)J recombinase
@en
P2093
David B Roth
Leslie E Huye
Mary M Purugganan
Ming-Ming Jiang
P2860
P304
P356
10.1128/MCB.22.10.3460-3473.2002
P407
P577
2002-05-01T00:00:00Z