Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination
about
Amino acid residues in RAG1 responsible for the interaction with RAG2 during the V(D)J recombination processThe RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2Flanking regulatory sequences of the Tetrahymena R deletion element determine the boundaries of DNA rearrangementDistinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaksKu and the Stability of the GenomeA functional analysis of the spacer of V(D)J recombination signal sequencesStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisResponse to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AXThe response to and repair of RAG-mediated DNA double-strand breaksComputational tools for understanding sequence variability in recombination signalsPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1The taming of a transposon: V(D)J recombination and the immune systemAutoubiquitylation of the V(D)J recombinase protein RAG1Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombinationMutations of acidic residues in RAG1 define the active site of the V(D)J recombinaseElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingSelf-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent.RAG2's acidic hinge restricts repair-pathway choice and promotes genomic stability.HMGB1: roles in base excision repair and related function.DNA hairpin opening mediated by the RAG1 and RAG2 proteins.HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase.Differential requirements for cis and trans V(D)J cleavage: effects of substrate lengthNon-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Effect of HIV integrase inhibitors on the RAG1/2 recombinase.Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleIntermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.RAG-2 promotes heptamer occupancy by RAG-1 in the assembly of a V(D)J initiation complex.Detection of RAG protein-V(D)J recombination signal interactions near the site of DNA cleavage by UV cross-linking.A RAG1 and RAG2 tetramer complex is active in cleavage in V(D)J recombination.Mechanistic basis for coding end sequence effects in the initiation of V(D)J recombinationPostcleavage sequence specificity in V(D)J recombination.Irradiation promotes V(D)J joining and RAG-dependent neoplastic transformation in SCID T-cell precursors.The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombinationConditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.A C-terminal region of RAG1 contacts the coding DNA during V(D)J recombination.Rag-1 mutations associated with B-cell-negative scid dissociate the nicking and transesterification steps of V(D)J recombination.Functional organization of single and paired V(D)J cleavage complexes
P2860
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P2860
Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@ast
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@en
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@nl
type
label
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@ast
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@en
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@nl
prefLabel
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@ast
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@en
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@nl
P3181
P1433
P1476
Assembly of a 12/23 paired sig ...... l point in V(D)J recombination
@en
P2093
P304
P3181
P356
10.1016/S1097-2765(00)80101-X
P407
P577
1998-06-01T00:00:00Z