Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy. - Wikidata - awgldk - TriplyDB

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

http://www.wikidata.org/entity/Q34279254

about

Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy Nanopatterned Human iPSC-Based Model of a Dystrophin-Null Cardiomyopathic Phenotype Nitric oxide synthases in heart failure Pre-clinical drug tests in the mdx mouse as a model of dystrophinopathies: an overview Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS The role of fibrosis in Duchenne muscular dystrophy Swimming into prominence: the zebrafish as a valuable tool for studying human myopathies and muscular dystrophies.Dasatinib as a treatment for Duchenne muscular dystrophy Loss of the cytoskeletal protein Pdlim7 predisposes mice to heart defects and hemostatic dysfunction Phosphodiesterases and cardiac cGMP: evolving roles and controversies Current understanding of molecular pathology and treatment of cardiomyopathy in duchenne muscular dystrophy Treatment with a nitric oxide-donating NSAID alleviates functional muscle ischemia in the mouse model of Duchenne muscular dystrophy The Effect of Sorafenib, Tadalafil and Macitentan Treatments on Thyroxin-Induced Hemodynamic Changes and Cardiac Abnormalities Recent advances using zebrafish animal models for muscle disease drug discovery Applications of chemogenomic library screening in drug discovery The maintenance ability and Ca2+ availability of skeletal muscle are enhanced by sildenafil Drug screening in a zebrafish model of Duchenne muscular dystrophy.PDE5 inhibition alleviates functional muscle ischemia in boys with Duchenne muscular dystrophy.The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish.Advances in targeting cyclic nucleotide phosphodiesterases Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis.Sildenafil use and increased risk of incident melanoma in US men: a prospective cohort study Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection.Sildenafil does not improve cardiomyopathy in Duchenne/Becker muscular dystrophy.Zebrafish based small molecule screens for novel DMD drugs.Cyclic nucleotide phosphodiesterases: important signaling modulators and therapeutic targets.Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling.Nitric oxide signalling pathway in Duchenne muscular dystrophy mice: up-regulation of L-arginine transporters.PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy.Dystrophin-glycoprotein complex regulates muscle nitric oxide production through mechanoregulation of AMPK signaling Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy.Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition Vascular-targeted therapies for Duchenne muscular dystrophy Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G.Microtubule-Mediated Misregulation of Junctophilin-2 Underlies T-Tubule Disruptions and Calcium Mishandling in mdx Mice.Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A.Therapeutic advances in muscular dystrophy Tadalafil alleviates muscle ischemia in patients with Becker muscular dystrophy.

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P2860

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

http://www.wikidata.org/entity/Q34279254

description

2010 nî lūn-bûn

@nan

2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2010 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@ast

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@en

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@nl

type

label

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@ast

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@en

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@nl

prefLabel

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@ast

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@en

Sildenafil reverses cardiac dy ...... f Duchenne muscular dystrophy.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Sildenafil reverses cardiac dy ...... of Duchenne muscular dystrophy

@en

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Candace M Adamo

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Elina Minami

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Enrico Patrucco

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Joseph A Beavo

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Justin M Percival

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Stanley C Froehner

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P2860

Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance

Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency

Long-term improvement in mdx cardiomyopathy after therapy with peptide-conjugated morpholino oligomers.

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.

Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging.

Oxidative stress regulates left ventricular PDE5 expression in the failing heart

Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

The heart in human dystrophinopathies.

Diastolic heart failure: challenges of diagnosis and treatment.

A nitric oxide synthase transgene ameliorates muscular dystrophy in mdx mice

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