TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
about
Interaction with PI3-kinase contributes to the cytotoxic activity of apoptinTargeting caspases in cancer therapeuticsE1A activates transcription of p73 and Noxa to induce apoptosisMapping of apoptin-interaction with BCR-ABL1, and development of apoptin-based targeted therapy.Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent.Potent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivoA novel anti-CD22 scFv-apoptin fusion protein induces apoptosis in malignant B-cells.Efficient production of an engineered apoptin from chicken anemia virus in a recombinant E. coli for tumor therapeutic applicationspH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous proteinTargeting Gene-Viro-Therapy with AFP driving Apoptin gene shows potent antitumor effect in hepatocarcinomaSelective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy.Polymers for drug delivery systems.Apoptin: specific killer of tumor cells?Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptinCombined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymesTransduction of Recombinant M3-p53-R12 Protein Enhances Human Leukemia Cell Apoptosis.Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.Secretory Transactivating Transcription-apoptin fusion protein induces apoptosis in hepatocellular carcinoma HepG2 cells.The chimeric multi-domain proteins mediating specific DNA transfer for hepatocellular carcinoma treatment.Novel characteristics of the avian gyrovirus 2 genome.Towards novel paradigms for cancer therapy.Naturally occurring, tumor-specific, therapeutic proteins.Mechanisms of Apoptin-induced cell death.Viral genes as oncolytic agents for cancer therapy.The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53.Human-gyrovirus-Apoptin triggers mitochondrial death pathway--Nur77 is required for apoptosis triggering.Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.AdHu5-apoptin induces G2/M arrest and apoptosis in p53-mutated human gastric cancer SGC-7901 cells.Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2.Delivery of therapeutic proteins as secretable TAT fusion products.PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers.Additive cytotoxic effect of apoptin and chemotherapeutic agents paclitaxel and etoposide on human tumour cells.Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor.A truncated apoptin protein variant selectively kills cancer cells.The large conductance calcium-activated potassium channel affects extrinsic and intrinsic mechanisms of apoptosisLocal non-viral gene delivery of apoptin delays the onset of paresis in an experimental model of intramedullary spinal cord tumor.Relevance of apoptin's integrity for its functional behavior.
P2860
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P2860
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@ast
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@en
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@nl
type
label
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@ast
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@en
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@nl
prefLabel
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@ast
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@en
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@nl
P2093
P356
P1433
P1476
TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells.
@en
P2093
Hugh Paterson
Joop Gäken
Lars Guelen
Mahvash Tavassoli
Michelle Meyers
P2888
P304
P356
10.1038/SJ.ONC.1207224
P407
P577
2004-02-01T00:00:00Z
P5875
P6179
1026072226