Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
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Reactive oxygen species-activated Akt/ASK1/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cellsS100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3Switching Akt: from survival signaling to deadly responseNetwork-level effects of kinase inhibitors modulate TNF-α-induced apoptosis in the intestinal epitheliumCyclin-dependent kinase activity controls the onset of the HCMV lytic cycleModeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug designPotent anti-tumor effects of a dual specific oncolytic adenovirus expressing apoptin in vitro and in vivoPemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.MicroRNA-101-mediated Akt activation and estrogen-independent growth.Akt: a double-edged sword in cell proliferation and genome stability.Gallus Heat shock cognate protein 70, a novel binding partner of ApoptinEnhanced tumour cell nuclear targeting in a tumour progression model.Targeting Gene-Viro-Therapy with AFP driving Apoptin gene shows potent antitumor effect in hepatocarcinomaGenetic deletion and pharmacological inhibition of Akt1 isoform attenuates bladder cancer cell proliferation, motility and invasion.Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1).ROS-mediated activation of AKT induces apoptosis via pVHL in prostate cancer cellsSalmonella typhimurium mediated delivery of Apoptin in human laryngeal cancer.Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral ReplicationNuclear Akt: target for breast cancer therapy?Naturally occurring, tumor-specific, therapeutic proteins.Mechanisms of Apoptin-induced cell death.Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer.Viral genes as oncolytic agents for cancer therapy.Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.Apoptin selectively induces the apoptosis of tumor cells by suppressing the transcription of HSP70.Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2.Human Gyrovirus-Apoptin Interferes with the Cell Cycle and Induces G2/M Arrest Prior to Apoptosis.Identification of the first human gyrovirus, a virus related to chicken anemia virus.Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer.Marek’s disease virus oncoprotein Meq physically interacts with the chicken infectious anemia virus-encoded apoptotic protein apoptin.
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P2860
Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 22 December 2008
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Unscheduled Akt-triggered acti ...... apoptin's anticancer toxicity.
@en
Unscheduled Akt-triggered acti ...... apoptin's anticancer toxicity.
@nl
type
label
Unscheduled Akt-triggered acti ...... apoptin's anticancer toxicity.
@en
Unscheduled Akt-triggered acti ...... apoptin's anticancer toxicity.
@nl
prefLabel
Unscheduled Akt-triggered acti ...... apoptin's anticancer toxicity.
@en
Unscheduled Akt-triggered acti ...... apoptin's anticancer toxicity.
@nl
P2093
P2860
P356
P1476
Unscheduled Akt-triggered acti ...... apoptin's anticancer toxicity
@en
P2093
Emilia Wiechec
Klaus Schulze-Osthoff
Soumya Panigrahi
Subbareddy Maddika
Ute Fischer
P2860
P304
P356
10.1128/MCB.00668-08
P407
P577
2008-12-22T00:00:00Z