Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients. - Wikidata - awgldk - TriplyDB

Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients.

Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients.

http://www.wikidata.org/entity/Q34286189

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Fibulin-4 regulates expression of the tropoelastin gene and consequent elastic-fibre formation by human fibroblasts Visualizing tropoelastin in a long-term human elastic fibre cell culture model Versican and the regulation of cell phenotype in disease Expression of versican isoform V3 in the absence of ascorbate improves elastogenesis in engineered vascular constructs.Versican and the control of inflammation.Alteration of chondroitin sulfate composition on proteoglycan produced by knock-in mouse embryonic fibroblasts whose versican lacks the A subdomain.Expression of versican V3 by arterial smooth muscle cells alters tumor growth factor β (TGFβ)-, epidermal growth factor (EGF)-, and nuclear factor κB (NFκB)-dependent signaling pathways, creating a microenvironment that resists monocyte adhesion.The hyperthermia-enhanced association between tropoelastin and its 67-kDa chaperone results in better deposition of elastic fibers.Arterial pathology in canine mucopolysaccharidosis-I and response to therapy Insight into pathologic abnormalities in congenital semilunar valve disease based on advances in understanding normal valve microstructure and extracellular matrix.Neointima formed by arterial smooth muscle cells expressing versican variant V3 is resistant to lipid and macrophage accumulation Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes Tumor predisposition in Costello syndrome.Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections.Changes in elastin, elastin binding protein and versican in alveoli in chronic obstructive pulmonary disease Cutaneous manifestations of Costello syndrome.Inhibition of versican expression by siRNA facilitates tropoelastin synthesis and elastic fiber formation by human SK-LMS-1 leiomyosarcoma smooth muscle cells in vitro and in vivo.G1 Domain of Versican Regulates Hyaluronan Organization and the Phenotype of Cultured Human Dermal Fibroblasts.The mucopolysaccharidoses: a success of molecular medicine.Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointimae after vascular injury Pro-inflammatory phenotype of COPD fibroblasts not compatible with repair in COPD lung.The bladder extracellular matrix. Part I: architecture, development and disease.The intracellular form of human MAGP1 elicits a complex and specific transcriptional response.Primary and secondary elastin-binding protein defect leads to impaired elastogenesis in fibroblasts from GM1-gangliosidosis patients.Provisional matrix: A role for versican and hyaluronan.C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome.The role of elastic fibers in pathogenesis of conjunctivochalasis.Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts.V3 versican isoform expression alters the phenotype of melanoma cells and their tumorigenic potential.Expression and localization of versican during postnatal development of rat temporomandibular joint disc.Decellularization and Solubilization of Porcine Liver for Use as a Substrate for Porcine Hepatocyte Culture: Method Optimization and Comparison.Proteoglycan expression is influenced by mechanical load in TMJ discs.Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin.

P2860

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P2860

Retrovirally mediated overexpression of versican v3 reverses impaired elastogenesis and heightened proliferation exhibited by fibroblasts from Costello syndrome and Hurler disease patients.

http://www.wikidata.org/entity/Q34286189

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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Retrovirally mediated overexpr ...... e and Hurler disease patients.

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Retrovirally mediated overexpr ...... e and Hurler disease patients.

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Retrovirally mediated overexpr ...... e and Hurler disease patients.

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Retrovirally mediated overexpr ...... e and Hurler disease patients.

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The American Journal of Pathology

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Retrovirally mediated overexpr ...... e and Hurler disease patients.

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Aleksander Hinek

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Kathy R Braun

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Kela Liu

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Thomas N Wight

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Yanting Wang

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P2860

Elastin is an essential determinant of arterial morphogenesis

Impaired elastic-fiber assembly by fibroblasts from patients with either Morquio B disease or infantile GM1-gangliosidosis is linked to deficiency in the 67-kD spliced variant of beta-galactosidase.

Versican/PG-M isoforms in vascular smooth muscle cells

The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding

Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues

The 67-kDa enzymatically inactive alternatively spliced variant of beta-galactosidase is identical to the elastin/laminin-binding protein

Biological roles of the non-integrin elastin/laminin receptor

A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican

Nature and the multiple functions of the 67-kD elastin-/laminin binding protein

A new syndrome: mental subnormality and nasal papillomata

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1602235

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