Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step
about
APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.Human OGG1 undergoes serine phosphorylation and associates with the nuclear matrix and mitotic chromatin in vivoModification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnoverXRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactionsRedox regulation of human OGG1 activity in response to cellular oxidative stressUracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanismsProcessing of a complex multiply damaged DNA site by human cell extracts and purified repair proteinsAPE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instabilityKinetics of substrate recognition and cleavage by human 8-oxoguanine-DNA glycosylaseOxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance.Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylaseEmerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical exampleCharacterization of AP lyase activities of Saccharomyces cerevisiae Ntg1p and Ntg2p: implications for biological function.Base Excision Repair, a Pathway Regulated by Posttranslational ModificationsSubstrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activityRole of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1In vitro and in vivo dimerization of human endonuclease III stimulates its activityThe main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosineExcision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylaseDNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extractsExpression changes in DNA repair enzymes and mitochondrial DNA damage in aging rat lensComplexities of the DNA base excision repair pathway for repair of oxidative DNA damageA quantitative model of human DNA base excision repair. I. Mechanistic insights.A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidisInsights into the glycosylase search for damage from single-molecule fluorescence microscopy.Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937Characterization of DNA glycosylase activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanineCommon polymorphisms of the hOGG1, APE1 and XRCC1 genes correlate with the susceptibility and clinicopathological features of primary angle-closure glaucomaReconstitution of the base excision repair pathway for 7,8-dihydro-8-oxoguanine with purified human proteinsAP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site ProductNucleosomes suppress the formation of double-strand DNA breaks during attempted base excision repair of clustered oxidative damagesTelomere proteins POT1, TRF1 and TRF2 augment long-patch base excision repair in vitro.Recent advances in the structural mechanisms of DNA glycosylasesAcetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivoAccumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection.Influence of DNA torsional rigidity on excision of 7,8-dihydro-8-oxo-2'-deoxyguanosine in the presence of opposing abasic sites by human OGG1 proteinClustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survivalNew functions of XPC in the protection of human skin cells from oxidative damageIncidence and persistence of 8-oxo-7,8-dihydroguanine within a hairpin intermediate exacerbates a toxic oxidation cycle associated with trinucleotide repeat expansion
P2860
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P2860
Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
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2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
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2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Mechanism of stimulation of th ...... of the AP lyase activity step
@ast
Mechanism of stimulation of th ...... of the AP lyase activity step
@en
Mechanism of stimulation of th ...... of the AP lyase activity step
@nl
type
label
Mechanism of stimulation of th ...... of the AP lyase activity step
@ast
Mechanism of stimulation of th ...... of the AP lyase activity step
@en
Mechanism of stimulation of th ...... of the AP lyase activity step
@nl
prefLabel
Mechanism of stimulation of th ...... of the AP lyase activity step
@ast
Mechanism of stimulation of th ...... of the AP lyase activity step
@en
Mechanism of stimulation of th ...... of the AP lyase activity step
@nl
P2860
P356
P1476
Mechanism of stimulation of th ...... of the AP lyase activity step
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P2093
I D Hickson
P2860
P304
P356
10.1093/NAR/29.6.1285
P407
P577
2001-03-01T00:00:00Z