Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer. - Wikidata - awgldk - TriplyDB

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.

http://www.wikidata.org/entity/Q34288659

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O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients Epigenetics of cervical cancer. An overview and therapeutic perspectives Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer The implications of heterogeneous DNA methylation for the accurate quantification of methylation A distinct epigenetic signature at targets of a leukemia protein.Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation Activity of temozolomide in patients with advanced chemorefractory colorectal cancer and MGMT promoter methylation.Trial of a 5-day dosing regimen of temozolomide in patients with relapsed small cell lung cancers with assessment of methylguanine-DNA methyltransferase.Current data and strategy in glioblastoma multiforme Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation O6-Methylguanine-DNA methyltransferase protein expression by immunohistochemistry in brain and non-brain systemic tumours: systematic review and meta-analysis of correlation with methylation-specific polymerase chain reaction.Promoter Methylation in Prostate Cancer and its Application for the Early Detection of Prostate Cancer Using Serum and Urine Samples.Epigenetic changes in prostate cancer: implication for diagnosis and treatment.Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis.MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.Epigenetic gene silencing in cancer: the DNA hypermethylome.DNA methylation profile distinguishes clear cell sarcoma of the kidney from other pediatric renal tumors Role of MGMT as biomarker in colorectal cancer.Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile.The role of O(6)-methylguanine-DNA methyltransferase polymorphisms in colorectal cancer susceptibility: a meta analysis.Aberrant DNA methylation and prostate cancer.Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas Mutually exclusive promoter hypermethylation patterns of hMLH1 and O6-methylguanine DNA methyltransferase in colorectal cancer.Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design Small cell lung cancer: will recent progress lead to improved outcomes?DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy Novel therapeutic approaches for small cell lung cancer: the future has arrived Telomerase: a potential therapeutic target for cancer.Prognosis value of MGMT promoter methylation for patients with lung cancer: a meta-analysis.Applying whole-genome studies of epigenetic regulation to study human disease.DNA repair gene variants in relation to overall cancer risk: a population-based study Mechanisms of chemoresistance to alkylating agents in malignant glioma.Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications.The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors.Cancer pharmacogenomics: role of DNA repair genetic polymorphisms in individualizing cancer therapy.Bendamustine as a model for the activity of alkylating agents.Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients.DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A.

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P2860

Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.

http://www.wikidata.org/entity/Q34288659

description

2004 nî lūn-bûn

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2004 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2004 թվականի հունվարին հրատարակված գիտական հոդված

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2004年の論文

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Generating mutations but provi ...... yltransferase in human cancer.

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Generating mutations but provi ...... yltransferase in human cancer.

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Generating mutations but provi ...... yltransferase in human cancer.

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James G Herman

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Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes

Clinical relevance of MGMT in the treatment of cancer.

Next-nucleotide effects in mutations driven by DNA precursor pool imbalances at the aprt locus of Chinese hamster ovary cells.

Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.

Mammalian mutator mutant with an aphidicolin-resistant DNA polymerase alpha.

Mutational specificity of alkylating agents and the influence of DNA repair.

Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli.

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