NRF2 and cancer: the good, the bad and the importance of context. - Wikidata - awgldk - TriplyDB

NRF2 and cancer: the good, the bad and the importance of context.

NRF2 and cancer: the good, the bad and the importance of context.

http://www.wikidata.org/entity/Q34289003

about

Metabolic, autophagic, and mitophagic activities in cancer initiation and progression NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer Cancer drug resistance: redox resetting renders a way The mutational landscape of hepatocellular carcinoma p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance An overview on the role of dietary phenolics for the treatment of cancers Epigenetic regulation of Keap1-Nrf2 signaling Essential role of PH domain and leucine-rich repeat protein phosphatase 2 in Nrf2 suppression via modulation of Akt/GSK3β/Fyn kinase axis during oxidative hepatocellular toxicity Clinicopathologic significance of CXCR4 and Nrf2 in colorectal cancer Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter Discovery and development of natural product oridonin-inspired anticancer agents The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer Nrf2 Induces IL-17D to Mediate Tumor and Virus Surveillance Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1 Progress and prospects of reactive oxygen species in metal carcinogenesis The complexity of the Nrf2 pathway: beyond the antioxidant response Nrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in Mice Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.Unique pattern of component gene disruption in the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in serous ovarian cancer Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?Cytoprotection "gone astray": Nrf2 and its role in cancer RETRACTED: Antioncogenic and Oncogenic Properties of Nrf2 in Arsenic-induced Carcinogenesis Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine Redox homeostasis: the linchpin in stem cell self-renewal and differentiation ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells NRF2-regulation in brain health and disease: implication of cerebral inflammation Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects HDAC inhibitors increase NRF2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents Rising levels of atmospheric oxygen and evolution of Nrf2 Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer T-REX on-demand redox targeting in live cells.NRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cells ROS function in redox signaling and oxidative stress Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.Non-thermal plasma activates human keratinocytes by stimulation of antioxidant and phase II pathways.

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NRF2 and cancer: the good, the bad and the importance of context.

http://www.wikidata.org/entity/Q34289003

description

2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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NRF2 and cancer: the good, the bad and the importance of context.

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Nature Reviews Cancer

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NRF2 and cancer: the good, the bad and the importance of context

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Michael B Sporn

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P2860

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

Suppression of NF-kappaB signaling by KEAP1 regulation of IKKbeta activity through autophagic degradation and inhibition of phosphorylation

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

The consensus coding sequences of human breast and colorectal cancers

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

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