The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
about
Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Growth arrest-specific 1 binds to and controls the maturation and processing of the amyloid-beta precursor proteinIdentification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseaseGpr3 stimulates Aβ production via interactions with APP and β-arrestin2Pathways towards and away from Alzheimer's diseaseEpigenetic Alterations in Alzheimer's DiseaseGetting to NO Alzheimer's Disease: Neuroprotection versus Neurotoxicity Mediated by Nitric OxideThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationBehavioral assays with mouse models of Alzheimer's disease: practical considerations and guidelines.Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): a paradigm worth exploringMolecular mechanisms of disease-causing missense mutationsImpact of age on the cerebrovascular proteomes of wild-type and Tg-SwDI micePresumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiencyCurrent and future implications of basic and translational research on amyloid-β peptide production and removal pathwaysTrafficking and proteolytic processing of APPFe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor proteinCdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease modelsAlzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid raftsRole of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesisThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues.Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions.BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and ratsRapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway.Copper promotes the trafficking of the amyloid precursor proteinEarly accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation.Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic miceCognitive impairment in the Tg6590 transgenic rat model of Alzheimer's diseaseFAD mutations in amyloid precursor protein do not directly perturb intracellular calcium homeostasis.Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease.The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic miceAscidians: an invertebrate chordate model to study Alzheimer's disease pathogenesis.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.α-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.Prodomain processing of Asp1 (BACE2) is autocatalytic.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance.Regulation of APP cleavage by alpha-, beta- and gamma-secretases.
P2860
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P2860
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
description
1995 nî lūn-bûn
@nan
1995 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
name
The Swedish mutation causes ea ...... within the secretory pathway.
@ast
The Swedish mutation causes ea ...... within the secretory pathway.
@en
The Swedish mutation causes ea ...... within the secretory pathway.
@nl
type
label
The Swedish mutation causes ea ...... within the secretory pathway.
@ast
The Swedish mutation causes ea ...... within the secretory pathway.
@en
The Swedish mutation causes ea ...... within the secretory pathway.
@nl
prefLabel
The Swedish mutation causes ea ...... within the secretory pathway.
@ast
The Swedish mutation causes ea ...... within the secretory pathway.
@en
The Swedish mutation causes ea ...... within the secretory pathway.
@nl
P2093
P356
P1433
P1476
The Swedish mutation causes ea ...... within the secretory pathway.
@en
P2093
Lannfelt L
P2888
P304
P356
10.1038/NM1295-1291
P407
P577
1995-12-01T00:00:00Z