RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. - Wikidata - awgldk - TriplyDB

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

http://www.wikidata.org/entity/Q34290557

about

RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response The proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break response PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair PIAS3 promotes homology‑directed repair and distal non‑homologous end joining Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair Functions of Ubiquitin and SUMO in DNA Replication and Replication Stress Choreographing the Double Strand Break Response: Ubiquitin and SUMO Control of Nuclear Architecture Interplay between Ubiquitin, SUMO, and Poly(ADP-Ribose) in the Cellular Response to Genotoxic Stress How SUMOylation Fine-Tunes the Fanconi Anemia DNA Repair Pathway Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks Cooperativity of the SUMO and Ubiquitin Pathways in Genome Stability Role of Deubiquitinating Enzymes in DNA Repair RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response Function and regulation of SUMO proteases Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells.Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3 Ubiquitylation, neddylation and the DNA damage response Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair USP7 is a SUMO deubiquitinase essential for DNA replication SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage Exploring the RING-catalyzed ubiquitin transfer mechanism by MD and QM/MM calculations.An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.Small ubiquitin-like modifier (SUMO) isoforms and conjugation-independent function in DNA double-strand break repair pathways RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage.Ube2W conjugates ubiquitin to α-amino groups of protein N-termini Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites.Identification of novel interacting partners of Sirtuin6.Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.Concerted action of the ubiquitin-fusion degradation protein 1 (Ufd1) and Sumo-targeted ubiquitin ligases (STUbLs) in the DNA-damage response.SUMO proteomics to decipher the SUMO-modified proteome regulated by various diseases.RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability.

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RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

http://www.wikidata.org/entity/Q34290557

description

2012 nî lūn-bûn

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հունիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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name

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@ast

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@en

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@nl

type

label

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@ast

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@en

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@nl

prefLabel

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@ast

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@en

RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@nl

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Genes & Development

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RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.

@en

P2093

Julia Coates

http://www.w3.org/2001/XMLSchema#string

Rimma Belotserkovskaya

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P2860

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

Purified human BRCA2 stimulates RAD51-mediated recombination

A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

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1179-1195

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scholarly article

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10.1101/GAD.188284.112

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11

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26

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Stephen P Jackson

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2012-06-01T00:00:00Z

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225095336

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22661229

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3371407

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