CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function.
about
Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergyThe modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cellsEctopic expression of a truncated CD40L protein from synthetic post-transcriptionally capped RNA in dendritic cells induces high levels of IL-12 secretion.Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradationPathogen-Reactive T Helper Cell Analysis in the PigClonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method.Activation of tolerogenic dendritic cells in the tumor draining lymph nodes by CD8+ T cells engineered to express CD40 ligand.In vivo post-transcriptional regulation of CD154 in mouse CD4+ T cells.Regulation of human immunodeficiency virus type 1 infection, beta-chemokine production, and CCR5 expression in CD40L-stimulated macrophages: immune control of viral entry.Down-regulation of cell surface receptors is modulated by polar residues within the transmembrane domain.Identification of Mycobacterium tuberculosis-specific Th1, Th17 and Th22 cells using the expression of CD40L in tuberculous pleurisy.Depressed CD40 ligand expression contributes to reduced gamma interferon production in human tuberculosisPreformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival.IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist.Polyfunctional T cell responses in children in early stages of chronic Trypanosoma cruzi infection contrast with monofunctional responses of long-term infected adults.Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40 ligand mediates antigen-specific T cell help in vitro.The dinucleotide repeat polymorphism in the 3'UTR of the CD154 gene has a functional role on protein expression and is associated with systemic lupus erythematosus.Bone marrow-derived cells are required for the induction of a pulmonary inflammatory response mediated by CD40 ligation.Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells.Human CD14hi monocytes and myeloid dendritic cells provide a cell contact-dependent costimulatory signal for early CD40 ligand expressionPreformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific mannerRapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signalingSAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation.A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaBConcurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosisThe biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: reciprocal regulation by interleukin (IL)-4 and IL-12.CD40 ligand (CD154) triggers a short-term CD4(+) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosisDifferential modulation by delta9-tetrahydrocannabinol (∆9)-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cellsCD40 promotes MHC class II expression on adipose tissue macrophages and regulates adipose tissue CD4+ T cells with obesity.Selected Toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells.Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production.Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes.Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.CD40 and the immune response to parasitic infections.Detection of Foreign Antigen-specific CD4(+)Foxp3(+) Regulatory T Cells by MHC Class II Tetramer and Intracellular CD154 Staining.Transcriptome Analysis of Mycobacteria-Specific CD4+ T Cells Identified by Activation-Induced Expression of CD154.Functional analysis of a tripartite stability element within the CD40 ligand 3' untranslated region.The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation.
P2860
Q24597077-0DD9F5D5-7EA7-4250-9511-2635FEAE89F1Q28115032-8E739671-BAFE-4E5D-BD82-6DA3D2334E70Q33377577-337F8A87-E4AB-4894-B24D-39C48A1DBC3DQ33676528-D11F0DFA-AA9C-4F49-B6E4-05CB84B9B60DQ33695173-656DB16E-094B-4CFF-83B9-7F2D6C6DCE66Q33721633-66B0481D-5399-480D-9A07-1FEE5579AD89Q33746583-02EAEDB7-6756-4627-9EAE-38AB21EC8A6BQ33797093-3CBE0D3D-38A2-4E9E-ADB5-7BB5E0BF04D5Q33839665-5D5C756B-6BB0-4CE3-8F5D-EB0D48E25E2FQ33912615-A29654EA-5900-492E-AB9A-9BBC37CBFFF3Q33916768-17DD93F5-8286-4AFC-8A7F-470797C2C677Q34004473-8E073E71-8246-4C0C-9046-357BA7BEFBD8Q34170759-DF390868-2114-475B-A2A8-FCA82348476BQ34634834-D829B8FC-8130-47E8-AE5F-51E9547416A4Q34702800-D15A1B16-1BAC-46F8-BB5F-2C5A1962A04BQ35022575-03AB6153-8C19-4D62-B2A9-208C3B35DB8EQ35071204-E716C26B-5192-43AB-A26D-CFF4B3A273EAQ35091423-F79F6836-57C2-430B-B428-963FCF6FBA2EQ35553871-0A70FD2F-A43B-4B81-BF5C-70CE5051073BQ35786333-7E541969-86E0-4E35-A942-CC594D2BDABDQ35819655-364EB303-CDF9-4818-8EFC-CE65593B8A5BQ35868342-275D58E9-A743-4A05-99FB-DE3564F9C552Q36007588-F82B89B8-F35B-4A5E-87F8-46D8B247A7F8Q36097323-581AE435-84AB-47B3-AFB2-4579748981E3Q36228622-08C3506C-7143-49D4-88AE-BA97D0129B57Q36365928-AC7CB5D6-6761-4A96-AAA3-E29F9F9E8A02Q36366395-57AD3F11-748D-4FEA-B85D-7F6B77C567D1Q36371081-404AE73B-B0CF-4030-B0A3-20CED22F0486Q36375941-D2328042-BAD9-4C4E-9DE7-D69B38AC4887Q36854921-C6324D0C-33D3-4178-AE3E-9ADB14051D48Q37111264-E61F278F-DA06-4B34-8647-72575614B3F6Q37223456-39505EB8-6101-4AC3-812F-A40C3633A3CCQ37354525-F688331F-4ED2-416A-ACDC-29631E54AD8FQ37358432-C76FAB1F-3FFE-4FCF-9E06-761226118275Q37374541-876C4E33-5A9F-4BC4-AAE8-B27D4F115796Q37377899-3C25B9A0-F553-478E-B16B-5CB010020420Q37420224-2128E80A-869E-4CE1-9B07-6EF7A2AA57EBQ38618031-BDE4FAA2-1D40-4C82-AF19-116CFEA53A3AQ40025338-3D866D35-78B2-4360-8127-6E389D3DF4F9Q41954955-934CEFDD-DBAE-4E8C-A846-A4FFC28E467A
P2860
CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40-L. Potential role in regulating helper effector function.
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
CD40 molecules induce down-mod ...... ting helper effector function.
@ast
CD40 molecules induce down-mod ...... ting helper effector function.
@en
CD40 molecules induce down-mod ...... ting helper effector function.
@nl
type
label
CD40 molecules induce down-mod ...... ting helper effector function.
@ast
CD40 molecules induce down-mod ...... ting helper effector function.
@en
CD40 molecules induce down-mod ...... ting helper effector function.
@nl
prefLabel
CD40 molecules induce down-mod ...... ting helper effector function.
@ast
CD40 molecules induce down-mod ...... ting helper effector function.
@en
CD40 molecules induce down-mod ...... ting helper effector function.
@nl
P2093
P1476
CD40 molecules induce down-mod ...... ting helper effector function.
@en
P2093
Inghirami G
Lederman S
P304
P407
P577
1994-01-01T00:00:00Z