Update on the use of nonhuman primate models for preclinical testing of gene therapy approaches targeting hematopoietic cells.
about
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cellsHematopoietic stem cell gene therapy:assessing the relevance of preclinical modelsPath to the clinic: assessment of iPSC-based cell therapies in vivo in a nonhuman primate model.Myeloid-lymphoid ontogeny in the rhesus monkey (Macaca mulatta).Repetitive busulfan administration after hematopoietic stem cell gene therapy associated with a dominant HDAC7 clone in a nonhuman primate.Contributions of gene marking to cell and gene therapies.Pigtailed macaques as a model to study long-term safety of lentivirus vector-mediated gene therapy for hemoglobinopathies.Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cellsAMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.Hematopoietic stem-cell behavior in nonhuman primatesStem cell gene transfer: insights into integration and hematopoiesis from primate genetic marking studies.Avoidance of stimulation improves engraftment of cultured and retrovirally transduced hematopoietic cells in primatesLarge animal models and gene therapy.Assessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cellsReconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques.Sustained high-level polyclonal hematopoietic marking and transgene expression 4 years after autologous transplantation of rhesus macaques with SIV lentiviral vector-transduced CD34+ cellsBetter leukemia-free and overall survival in AML in first remission following cyclophosphamide in combination with busulfan compared with TBI.No impact of lentiviral transduction on hematopoietic stem/progenitor cell telomere length or gene expression in the rhesus macaque model.Clonal tracking of rhesus macaque hematopoiesis highlights a distinct lineage origin for natural killer cellsOur journey to successful gene therapy for hemophilia B.Quantitative stability of hematopoietic stem and progenitor cell clonal output in rhesus macaques receiving transplants.The Role of Nonhuman Primate Animal Models in the Clinical Development of Pluripotent Stem Cell Therapies.Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells.Gene therapy to inhibit xenoantibody production using lentiviral vectors in non-human primates.Antibody-mediated lung endothelium targeting: in vivo model on primates.Geographic clonal tracking in macaques provides insights into HSPC migration and differentiation.Improving the Transduction of Bone Marrow-Derived Cells with an Integrase-Defective Lentiviral Vector.
P2860
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P2860
Update on the use of nonhuman primate models for preclinical testing of gene therapy approaches targeting hematopoietic cells.
description
2001 nî lūn-bûn
@nan
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Update on the use of nonhuman ...... targeting hematopoietic cells.
@ast
Update on the use of nonhuman ...... targeting hematopoietic cells.
@en
Update on the use of nonhuman ...... targeting hematopoietic cells.
@nl
type
label
Update on the use of nonhuman ...... targeting hematopoietic cells.
@ast
Update on the use of nonhuman ...... targeting hematopoietic cells.
@en
Update on the use of nonhuman ...... targeting hematopoietic cells.
@nl
prefLabel
Update on the use of nonhuman ...... targeting hematopoietic cells.
@ast
Update on the use of nonhuman ...... targeting hematopoietic cells.
@en
Update on the use of nonhuman ...... targeting hematopoietic cells.
@nl
P1433
P1476
Update on the use of nonhuman ...... targeting hematopoietic cells
@en
P2093
Donahue RE
P304
P356
10.1089/104303401300057289
P577
2001-04-01T00:00:00Z