STAT proteins: novel molecular targets for cancer drug discovery. - Wikidata - awgldk - TriplyDB

STAT proteins: novel molecular targets for cancer drug discovery.

STAT proteins: novel molecular targets for cancer drug discovery.

http://www.wikidata.org/entity/Q34293579

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STAT3 protein up-regulates Gα-interacting vesicle-associated protein (GIV)/Girdin expression, and GIV enhances STAT3 activation in a positive feedback loop during wound healing and tumor invasion/metastasis ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3 Central role of liver in anticancer and radioprotective activities of Toll-like receptor 5 agonist Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease Targeting the tumor microenvironment: JAK-STAT3 signaling Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone Plant sterols as anticancer nutrients: evidence for their role in breast cancer Molecular aspects of development and regulation of endometriosis STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy Cucurbitacins - An insight into medicinal leads from nature Tip60 is a co-repressor for STAT3 PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis Chemical probes that competitively and selectively inhibit Stat3 activation Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer Anticancer compound plumbagin and its molecular targets: a structural insight into the inhibitory mechanisms using computational approaches Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation STAT3 deletion sensitizes cells to oxidative stress Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer A novel role for signal transducer and activator of transcription 5b (STAT5b) in beta1-integrin-mediated human breast cancer cell migration.A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells.Muscadine grape skin extract reverts snail-mediated epithelial mesenchymal transition via superoxide species in human prostate cancer cells.Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity.Characterization of STAT3 activation and expression in canine and human osteosarcoma.Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis.Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation Oleanane triterpenoid CDDO-Me induces apoptosis in multidrug resistant osteosarcoma cells through inhibition of Stat3 pathway Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells.Salinomycin Abolished STAT3 and STAT1 Interactions and Reduced Telomerase Activity in Colorectal Cancer Cells.A cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro.Therapeutic modulators of STAT signalling for human diseases Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling.Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activation Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy

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STAT proteins: novel molecular targets for cancer drug discovery.

http://www.wikidata.org/entity/Q34293579

description

2000 nî lūn-bûn

@nan

2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

STAT proteins: novel molecular targets for cancer drug discovery.

@ast

STAT proteins: novel molecular targets for cancer drug discovery.

@en

STAT proteins: novel molecular targets for cancer drug discovery.

@nl

type

label

STAT proteins: novel molecular targets for cancer drug discovery.

@ast

STAT proteins: novel molecular targets for cancer drug discovery.

@en

STAT proteins: novel molecular targets for cancer drug discovery.

@nl

prefLabel

STAT proteins: novel molecular targets for cancer drug discovery.

@ast

STAT proteins: novel molecular targets for cancer drug discovery.

@en

STAT proteins: novel molecular targets for cancer drug discovery.

@nl

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STAT proteins: novel molecular targets for cancer drug discovery.

@en

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Jove R

http://www.w3.org/2001/XMLSchema#string

Turkson J

http://www.w3.org/2001/XMLSchema#string

P2860

Direct suppression of Stat1 function during adenoviral infection

A new protein containing an SH2 domain that inhibits JAK kinases

Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA

STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells.

Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylation

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

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6613-6626

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scholarly article

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10.1038/SJ.ONC.1204086

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56

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19

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2000-12-01T00:00:00Z

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11913343

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1015007460

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P698

11426647

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P921

positive regulation of tyrosine phosphorylation of STAT protein

regulation of tyrosine phosphorylation of STAT protein

negative regulation of tyrosine phosphorylation of STAT protein