Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). - Wikidata - awgldk - TriplyDB

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).

http://www.wikidata.org/entity/Q34294456

about

Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs The insights of Let-7 miRNAs in oncogenesis and stem cell potency Lin28 and let-7 in cell metabolism and cancer RNA Binding Proteins in the miRNA Pathway Surprises in the 3'-end: 'U' can decide too!Poly(A) polymerase (PAP) diversity in gene expression--star-PAP vs canonical PAP MicroRNA biogenesis pathways in cancer Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases Lin28: primal regulator of growth and metabolism in stem cells A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28-let-7 pathway Mechanism of Dis3l2 substrate recognition in the Lin28-let-7 pathway Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities.Lin28a regulates neuronal differentiation and controls miR-9 production.Dysregulation of miRNAs in bladder cancer: altered expression with aberrant biogenesis procedure Identification of small molecule inhibitors of the Lin28-mediated blockage of pre-let-7g processing Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing.Drosha protein levels are translationally regulated during Xenopus oocyte maturation Role of LIN28A in mouse and human trophoblast cell differentiation.The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses.Alteration of miRNA activity via context-specific modifications of Argonaute proteins.Selective microRNA uridylation by Zcchc6 (TUT7) and Zcchc11 (TUT4).Uridylation by TUT4 and TUT7 marks mRNA for degradation.Apoptosis Triggers Specific, Rapid, and Global mRNA Decay with 3' Uridylated Intermediates Degraded by DIS3L2 RNA-binding proteins in pluripotency, differentiation, and reprogramming.Lin28 induces epithelial-to-mesenchymal transition and stemness via downregulation of let-7a in breast cancer cells.Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.Deep sequencing shows multiple oligouridylations are required for 3' to 5' degradation of histone mRNAs on polyribosomes Signaling-mediated regulation of MicroRNA processing The yin and yang of kidney development and Wilms' tumors Adenylation of maternally inherited microRNAs by Wispy.Identification of small molecule inhibitors of Zcchc11 TUTase activity.TUT7 controls the fate of precursor microRNAs by using three different uridylation mechanisms.Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor.Destabilization of microRNAs in human cells by 3' deadenylation mediated by PARN and CUGBP1.A Single Let-7 MicroRNA Bypasses LIN28-Mediated Repression.Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival.MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1 Biogenesis and regulation of the let-7 miRNAs and their functional implications.The nucleic acid-binding domain and translational repression activity of a Xenopus terminal uridylyl transferase.

P2860

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P2860

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7).

http://www.wikidata.org/entity/Q34294456

description

2012 nî lūn-bûn

@nan

2012 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Lin28-mediated control of let- ...... hc11 (TUT4) and Zcchc6 (TUT7).

@ast

Lin28-mediated control of let- ...... hc11 (TUT4) and Zcchc6 (TUT7).

@en

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11

@nl

type

label

Lin28-mediated control of let- ...... hc11 (TUT4) and Zcchc6 (TUT7).

@ast

Lin28-mediated control of let- ...... hc11 (TUT4) and Zcchc6 (TUT7).

@en

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11

@nl

prefLabel

Lin28-mediated control of let- ...... hc11 (TUT4) and Zcchc6 (TUT7).

@ast

Lin28-mediated control of let- ...... hc11 (TUT4) and Zcchc6 (TUT7).

@en

Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11

@nl

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P2860

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P1476

Lin28-mediated control of let- ...... hc11 (TUT4) and Zcchc6 (TUT7).

@en

P2093

Elena Piskounova

http://www.w3.org/2001/XMLSchema#string

Hao-Ming Chang

http://www.w3.org/2001/XMLSchema#string

James E Thornton

http://www.w3.org/2001/XMLSchema#string

Richard I Gregory

http://www.w3.org/2001/XMLSchema#string

P2860

Efficient RNA polyuridylation by noncanonical poly(A) polymerases

TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation

Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

The Microprocessor complex mediates the genesis of microRNAs

Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells.

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans

MicroRNAs: target recognition and regulatory functions

Selective blockade of microRNA processing by Lin28

Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

P304

1875-1885

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P31

scholarly article

P356

10.1261/RNA.034538.112

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P407

P433

10

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P478

18

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P577

2012-08-16T00:00:00Z

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P698

22898984

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P921

microRNA expression

P932

3446710

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