Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor - Wikidata - awgldk - TriplyDB

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

http://www.wikidata.org/entity/Q34299265

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BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore The role of VDAC in cell death: friend or foe?Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial β-barrel anion channel hVDAC-2 Mitochondrial and postmitochondrial survival signaling in cancer.Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target Artesunate induces apoptosis via a Bak-mediated caspase-independent intrinsic pathway in human lung adenocarcinoma cells.Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.Mitochondria and apoptosis: emerging concepts.Bax dimerizes via a symmetric BH3:groove interface during apoptosis Characterization of Oyster Voltage-Dependent Anion Channel 2 (VDAC2) Suggests Its Involvement in Apoptosis and Host Defense MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals.Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.Quantitative proteomic analysis of mitochondrial proteins reveals prosurvival mechanisms in the perpetuation of radiation-induced genomic instability.Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome.Sirtuin-3 modulates Bak- and Bax-dependent apoptosis Physiological restraint of Bak by Bcl-xL is essential for cell survival.Two roads to death - Bax targets mitochondria by distinct routes before or during apoptotic cell death Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis Voltage-dependant anion channels: novel insights into isoform function through genetic models.Cellular and molecular mechanisms of mitochondrial function.Mitochondrial channels: ion fluxes and more."Licensed to kill": tyrosine dephosphorylation and Bak activation.Splitting up the powerhouse: structural insights into the mechanism of mitochondrial fission.Complex formation and turnover of mitochondrial transporters and ion channels.Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis.Targeting mitochondria: how intravacuolar bacterial pathogens manipulate mitochondria.Disordered clusters of Bak dimers rupture mitochondria during apoptosis.Identification of potential pathways involved in the induction of cell cycle arrest and apoptosis by a new 4-arylidene curcumin analogue T63 in lung cancer cells: a comparative proteomic analysis.The porin VDAC2 is the mitochondrial platform for Bax retrotranslocation.VDAC2-specific cellular functions and the underlying structure.Mitochondrial dynamics: functional link with apoptosis.Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.Concurrent and separate inside-out transition of platelet apoptosis and activation markers to the platelet surface.High-resolution proteomics and metabolomics in thyroid cancer: Deciphering novel biomarkers.Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.Respiratory chain enzyme deficiency induces mitochondrial location of actin-binding gelsolin to modulate the oligomerization of VDAC complexes and cell survival.Parkin promotes proteasomal degradation of misregulated BAX.

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P2860

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

http://www.wikidata.org/entity/Q34299265

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@ast

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@en

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@nl

type

label

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@ast

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@en

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@nl

prefLabel

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@ast

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@en

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@nl

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JBC.M110.159301

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Journal of Biological Chemistry

P1476

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

@en

P2093

Aneta Kotevski

http://www.w3.org/2001/XMLSchema#string

Ann E Frazier

http://www.w3.org/2001/XMLSchema#string

Grant Dewson

http://www.w3.org/2001/XMLSchema#string

William J Craigen

http://www.w3.org/2001/XMLSchema#string

P2860

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

Dissection of the mitochondrial import and assembly pathway for human Tom40

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease

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36876-36883

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scholarly article

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10.1074/JBC.M110.159301

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P433

47

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P478

285

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Diana Stojanovski

Michael Lazarou

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2010-09-17T00:00:00Z

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46306112

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20851889

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P921

transmembrane protein

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2978617

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