(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
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Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptorsNMDA receptor modulators: an updated patent review (2013-2014)Glutamate receptor ion channels: structure, regulation, and functionAn allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neuronesMapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptorA double-blind, placebo-controlled study of the safety, tolerability and pharmacokinetics of CP-101,606 in patients with a mild or moderate traumatic brain injury.N-methyl-D-aspartate antagonists for stroke and head trauma.Variations in the stimulus salience of cocaine reward influences drug-associated contextual memoryNew advances in NMDA receptor pharmacology.Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators.Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test.Role of altered structure and function of NMDA receptors in development of alcohol dependence.Differential Effects of an NR2B NAM and Ketamine on Synaptic Potentiation and Gamma Synchrony: Relevance to Rapid-Onset Antidepressant Efficacy.A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective AntagonistsPharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possiblyCocaine Self-Administration Elevates GluN2B within dmPFC Mediating Heightened Cue-Elicited Operant RespondingAllosteric modulators for the treatment of schizophrenia: targeting glutamatergic networksPharmacology of traumatic brain injury: where is the "golden bullet"?Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potentialPharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulatorsIon channel therapeutics for pain.Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors.Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism.Characterisation of N-methyl-D-aspartate receptor-specific [(3)H]Ifenprodil binding to recombinant human NR1a/NR2B receptors compared with native receptors in rodent brain membranes.A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine/D-serine.Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice.Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists.Involvement of NR2A- or NR2B-containing N-methyl-D-aspartate receptors in the potentiation of cortical layer 5 pyramidal neurone inputs depends on the developmental stage.Glutamate and tachykinin receptors in central sensitization of withdrawal reflexes in the decerebrated rabbit.Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex.Metabolism of CJ-036878, N-(3-phenethoxybenzyl)-4-hydroxybenzamide, in liver microsomes and recombinant cytochrome P450 enzymes: metabolite identification by LC-UV/MS(n) and (1)H-NMR.NMDA receptor NR2B subunit over-expression increases cerebellar granule cell migratory activity.NMDA Receptors in the Central Nervous System.A comparison of the effects of ketamine and phencyclidine with other antagonists of the NMDA receptor in rodent assays of attention and working memory.The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.Increased contribution of NR2A subunit to synaptic NMDA receptors in developing rat cortical neurons.CP-101,606: An NR2B-Selective NMDA Receptor Antagonist.Increased exon 5 expression alters extrasynaptic NMDA receptors in cerebellar neurons.
P2860
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P2860
(1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses.
description
1995 nî lūn-bûn
@nan
1995 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@ast
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@en
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@nl
type
label
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@ast
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@en
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@nl
prefLabel
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@ast
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@en
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@nl
P2093
P356
P1476
(1S,2S)-1-(4-hydroxyphenyl)-2- ...... -methyl-D-aspartate responses.
@en
P2093
Chambers LK
Chenard BL
Collins MA
De Costa DL
P304
P356
10.1021/JM00016A017
P407
P577
1995-08-01T00:00:00Z