Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators - Wikidata - awgldk - TriplyDB

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

http://www.wikidata.org/entity/Q37978091

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NMDA Receptor Function During Senescence: Implication on Cognitive Performance Novel NMDA receptor modulators: an update NMDA receptor modulators: an updated patent review (2013-2014)Drugs for allosteric sites on receptors Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Pharmacological enhancement of memory or cognition in normal subjects Intracranial self-stimulation to evaluate abuse potential of drugs.Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.Ketamine and phencyclidine: the good, the bad and the unexpected.MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit.Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators.The uncompetitive NMDA receptor antagonists ketamine and memantine preferentially increase the choice for a small, immediate reward in low-impulsive rats A family of photoswitchable NMDA receptors.Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers Allosteric modulators for the treatment of schizophrenia: targeting glutamatergic networks NMDA Receptor Antagonists for Treatment of Depression Potentiation of GluN2C/D NMDA receptor subtypes in the amygdala facilitates the retention of fear and extinction learning in mice.Influence of GluN2 subunit identity on NMDA receptor function.Calcium-permeable ion channels in pain signaling.New horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics.Modulation of excitatory neurotransmission by neuronal/glial signalling molecules: interplay between purinergic and glutamatergic systems.Enhancing NMDA Receptor Function: Recent Progress on Allosteric Modulators.A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors.Enzyme-luminescence method: Tool for real-time monitoring of natural neurotoxins in vitro and l-glutamate release from primary cortical neurons.Identification of potential Gly/NMDA receptor antagonists by cheminformatics approach: a combination of pharmacophore modelling, virtual screening and molecular docking studies.A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons.NMDA Receptors in the Central Nervous System.Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.The Structure-Activity Relationship of a Tetrahydroisoquinoline Class of N-Methyl-d-Aspartate Receptor Modulators that Potentiates GluN2B-Containing N-Methyl-d-Aspartate Receptors.D-serine-induced inactivation of NMDA receptors in cultured rat hippocampal neurons expressing NR2A subunits is Ca2+-dependent.Effects of N-Methyl-D-aspartate (NMDA) antagonists ketamine, methoxetamine, and phencyclidine on the odor span test of working memory in rats.An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups.Altered Synaptic and Extrasynaptic NMDA Receptor Properties in Substantia Nigra Dopaminergic Neurons From Mice Lacking the GluN2D Subunit

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Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators

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Pharmacological modulation of ...... positive allosteric modulators

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Pharmacological modulation of ...... ositive allosteric modulators.

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Pharmacological modulation of ...... ositive allosteric modulators.

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Pharmacological modulation of ...... positive allosteric modulators

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J.NEUINT.2012.01.004

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Neurochemistry International

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Pharmacological modulation of ...... positive allosteric modulators

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Blaise Mathias Costa

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Daniel T Monaghan

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David E Jane

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Guangyu Fang

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P2860

Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors

Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist

7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core

Probing the Allosteric Modulator Binding Site of GluR2 with Thiazide Derivatives

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

The glutamate receptor ion channels

Subtype-selective antagonism of N-methyl-D-aspartate receptors by felbamate: insights into the mechanism of action

Heteromeric NMDA receptors: molecular and functional distinction of subtypes

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581-592

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10.1016/J.NEUINT.2012.01.004

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4

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