Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
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Translational challenges of animal models in Chagas disease drug development: a reviewA new experimental model for assessing drug efficacy against Trypanosoma cruzi infection based on highly sensitive in vivo imagingHigh throughput screening for anti-Trypanosoma cruzi drug discoveryAptamer-based detection of disease biomarkers in mouse models for chagas drug discoveryThe Trypanosoma cruzi vitamin C dependent peroxidase confers protection against oxidative stress but is not a determinant of virulenceBreaking beta: deconstructing the parasite transmission functionEpidemiological modeling of Trypanosoma cruzi: Low stercorarian transmission and failure of host adaptive immunity explain the frequency of mixed infections in humansCD8(+) T cell-mediated immunity during Trypanosoma cruzi infection: a path for vaccine development?Drug strategies targeting CYP51 in neglected tropical diseasesDeep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversityDifferential phenotypic and functional profiles of TcCA-2 -specific cytotoxic CD8+ T cells in the asymptomatic versus cardiac phase in Chagasic patients.An enhanced chimeric firefly luciferase-inspired enzyme for ATP detection and bioluminescence reporter and imaging applications.Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis.Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas diseaseThe C-terminal region of Trypanosoma cruzi MASPs is antigenic and secreted via exovesicles.Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathyTrypanosoma cruzi: single cell live imaging inside infected tissues.Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.Chagas disease: still many unsolved issues.Chagas disease drug discovery: toward a new era.Autoimmune pathogenesis of Chagas heart disease: looking back, looking ahead.Red-emitting chimeric firefly luciferase for in vivo imaging in low ATP cellular environments.Bioluminescence Imaging to Detect Late Stage Infection of African Trypanosomiasis.Putting Infection Dynamics at the Heart of Chagas Disease.Multicolor bioluminescence boosts malaria research: quantitative dual-color assay and single-cell imaging in Plasmodium falciparum parasitesAnti-trypanosomatid drug discovery: an ongoing challenge and a continuing need.Biological factors that impinge on Chagas disease drug development.Susceptibility Testing of Medically Important Parasites.Insertion of Isocyanides into N-Si Bonds: Multicomponent Reactions with Azines Leading to Potent Antiparasitic Compounds.A multi-parametric analysis of Trypanosoma cruzi infection: common pathophysiologic patterns beyond extreme heterogeneity of host responses.Infectious diseases. Overcoming neglect of kinetoplastid diseases.In-vivo monitoring of infectious diseases in living animals using bioluminescence imaging.Drug Susceptibility of Genetically Engineered Trypanosoma cruzi Strains and Sterile Cure in Animal Models as a Criterion for Potential Clinical Efficacy of Anti-T. cruzi Drugs.Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes.Host triacylglycerols shape the lipidome of intracellular trypanosomes and modulate their growth.4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping.
P2860
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P2860
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Bioluminescence imaging of chr ...... locally persistent infection.
@ast
Bioluminescence imaging of chr ...... locally persistent infection.
@en
Bioluminescence imaging of chr ...... locally persistent infection.
@nl
type
label
Bioluminescence imaging of chr ...... locally persistent infection.
@ast
Bioluminescence imaging of chr ...... locally persistent infection.
@en
Bioluminescence imaging of chr ...... locally persistent infection.
@nl
prefLabel
Bioluminescence imaging of chr ...... locally persistent infection.
@ast
Bioluminescence imaging of chr ...... locally persistent infection.
@en
Bioluminescence imaging of chr ...... locally persistent infection.
@nl
P2093
P2860
P356
P1476
Bioluminescence imaging of chr ...... locally persistent infection.
@en
P2093
Alex P McLatchie
Amanda Fortes Francisco
John M Kelly
Martin C Taylor
Michael A Miles
P2860
P304
P356
10.1111/CMI.12297
P5008
P577
2014-05-01T00:00:00Z