about
The CK1 Family: Contribution to Cellular Stress Response and Its Role in CarcinogenesisThe phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repressionTwo sequence motifs from HIF-1alpha bind to the DNA-binding site of p53.Chromosomal instability at common fragile sites in Seckel syndromeDNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulationHypoxia and metabolic adaptation of cancer cellsDNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles' Heel of CancerRoles of Chk1 in cell biology and cancer therapySUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cellsHIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase.Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability.Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histonesRibonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA ReplicationProtection of cells in physiological oxygen tensions against DNA damage-induced apoptosisA nontranscriptional role for HIF-1α as a direct inhibitor of DNA replicationDNA instability at chromosomal fragile sites in cancerHIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia.Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment.Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells.Conditional mutation of Rb causes cell cycle defects without apoptosis in the central nervous system.The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.DNA damage during reoxygenation elicits a Chk2-dependent checkpoint responseMechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection.Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis.RecQ family helicases: roles as tumor suppressor proteins.Reciprocal influence of the p53 and the hypoxic pathwaysTargeting lung cancer through inhibition of checkpoint kinases.Infection, inflammation, and gastrointestinal cancer.Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKTHypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3γ inactivation of MDMX protein.Modeling the interplay between the HIF-1 and p53 pathways in hypoxiaCleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroidsMechanisms of early brain injury after subarachnoid hemorrhage.Mechanisms of chemoresistance in cancer stem cells.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX.Activation of Polo-like kinase 3 by hypoxic stresses.Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.Histone H2AX is integral to hypoxia-driven neovascularization.
P2860
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P2860
description
2002 nî lūn-bûn
@nan
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Hypoxia links ATR and p53 through replication arrest.
@ast
Hypoxia links ATR and p53 through replication arrest.
@en
Hypoxia links ATR and p53 through replication arrest.
@nl
type
label
Hypoxia links ATR and p53 through replication arrest.
@ast
Hypoxia links ATR and p53 through replication arrest.
@en
Hypoxia links ATR and p53 through replication arrest.
@nl
prefLabel
Hypoxia links ATR and p53 through replication arrest.
@ast
Hypoxia links ATR and p53 through replication arrest.
@en
Hypoxia links ATR and p53 through replication arrest.
@nl
P2093
P2860
P1476
Hypoxia links ATR and p53 through replication arrest.
@en
P2093
Amato J Giaccia
Ester M Hammond
Mary Jo Dorie
Nicholas C Denko
Robert T Abraham
P2860
P304
P356
10.1128/MCB.22.6.1834-1843.2002
P407
P577
2002-03-01T00:00:00Z