Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.
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A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinRegulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegenerationProtein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signallingHyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer diseaseMolecular Mechanisms in the Pathogenesis of Alzheimer's disease and Tauopathies-Prion-Like Seeded Aggregation and PhosphorylationBrain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathiesDeveloping therapeutic approaches to tau, selected kinases, and related neuronal protein targetsTau and tauopathiesThe preclinical phase of the pathological process underlying sporadic Alzheimer's diseaseThe use of cerebrospinal fluid and neuropathologic studies in neuropsychiatry practice and researchComparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's diseaseCoupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of TauPhosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau proteinStaging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathyRapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylationGenotype-specific differences between mouse CNS stem cell lines expressing frontotemporal dementia mutant or wild type human tauIndividual Case Analysis of Postmortem Interval Time on Brain Tissue PreservationZebrafish models of TauopathyPhosphorylation state-specific antibodies: applications in investigative and diagnostic pathology.In situ visualization of intratumor growth factor signaling: immunohistochemical localization of activated ERK/MAP kinase in glial neoplasms.Tau isoform regulation is region- and cell-specific in mouse brain.Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.Pseudophosphorylation and glycation of tau protein enhance but do not trigger fibrillization in vitro.Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.Total and phosphorylated tau protein as biological markers of Alzheimer's disease.Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function.ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegenerationCytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.Staging of Alzheimer's pathology in triple transgenic mice: a light and electron microscopic analysis.Pseudophosphorylation of tau protein directly modulates its aggregation kinetics.Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease.Genetic modifiers of tauopathy in Drosophila.Oligomer formation of tau protein hyperphosphorylated in cells.Neurofibrillary degeneration in amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam. Immunochemical characterization of tau proteins.Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic targetJoint assessment of structural, perfusion, and diffusion MRI in Alzheimer's disease and frontotemporal dementia.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.
P2860
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P2860
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Biopsy-derived adult human bra ...... e paired helical filament tau.
@ast
Biopsy-derived adult human bra ...... e paired helical filament tau.
@en
Biopsy-derived adult human bra ...... e paired helical filament tau.
@nl
type
label
Biopsy-derived adult human bra ...... e paired helical filament tau.
@ast
Biopsy-derived adult human bra ...... e paired helical filament tau.
@en
Biopsy-derived adult human bra ...... e paired helical filament tau.
@nl
prefLabel
Biopsy-derived adult human bra ...... e paired helical filament tau.
@ast
Biopsy-derived adult human bra ...... e paired helical filament tau.
@en
Biopsy-derived adult human bra ...... e paired helical filament tau.
@nl
P2093
P1433
P1476
Biopsy-derived adult human bra ...... e paired helical filament tau.
@en
P2093
Billingsley ML
O'Connor M
Trojanowski JQ
Van deVoorde A
P304
P356
10.1016/0896-6273(94)90264-X
P407
P577
1994-10-01T00:00:00Z